+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage



Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage



International Journal of Nephrology 2012: 681473



Uropathogenic Escherichia coli (UPEC) is a causative agent in the vast majority of urinary tract infections (UTIs), including cystitis and pyelonephritis, and infectious complications, which may result in acute renal failure in healthy individuals as well as in renal transplant patients. UPEC expresses a multitude of virulence factors to break the inertia of the mucosal barrier. In response to the breach by UPEC into the normally sterile urinary tract, host inflammatory responses are triggered leading to cytokine production, neutrophil influx, and the exfoliation of infected bladder epithelial cells. Several signaling pathways activated during UPEC infection, including the pathways known to activate the innate immune response, interact with calcium-dependent signaling pathways. Some UPEC isolates, however, might possess strategies to delay or suppress the activation of components of the innate host response in the urinary tract. Studies published in the recent past provide new information regarding how virulence factors of uropathogenic E. coli are involved in activation of the innate host response. Despite numerous host defense mechanisms, UPEC can persist within the urinary tract and may serve as a reservoir for recurrent infections and serious complications. Presentation of the molecular details of these events is essential for development of successful strategies for prevention of human UTIs and urological complications associated with UTIs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055600041

Download citation: RISBibTeXText

PMID: 22506110

DOI: 10.1155/2012/681473


Related references

Virulence Factors of Uropathogenic and Commensal Escherichia Coli Pathotypes in Patients with Urinary Tract Infection. Archives of Disease in Childhood 97(Suppl 2): A263-A264, 2012

Assessment of the significance of virulence factors of uropathogenic Escherichia coli in experimental urinary tract infection in mice. Microbiology and Immunology 40(9): 607-610, 1996

Prevalence of virulence factors and phylogenetic characterization of uropathogenic Escherichia coli causing urinary tract infection in patients with and without diabetes mellitus. Transactions of the Royal Society of Tropical Medicine and Hygiene 109(12): 769-774, 2015

Comparison of virulence factors and expression of specific genes between uropathogenic Escherichia coli and avian pathogenic E. coli in a murine urinary tract infection model and a chicken challenge model. Microbiology 155(Pt 5): 1634-1644, 2009

Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Current Opinion in Microbiology 16(1): 100-107, 2013

Distribution of uropathogenic virulence genes in Escherichia coli isolated from patients with urinary tract infection. International Journal of Infectious Diseases 17(6): E450-E453, 2013

Virulence properties of uropathogenic Escherichia coli isolated from children with urinary tract infection in Korea. Genes and Genomics 40(6): 625-634, 2018

Virulence factors of uropathogenic Escherichia coli of urinary tract infections and asymptomatic bacteriuria in children. Journal of Microbiology Immunology and Infection 47(6): 455-461, 2014

Assessment of a putative virulence factor of uropathogenic Escherichia coli in experimental urinary tract infection model. Journal of Urology 163(4 Suppl ): 11, 2000

The presence of the virulence island containing the usp gene in uropathogenic Escherichia coli is associated with urinary tract infection in an experimental mouse model. Journal of Urology 165(4): 1347-1351, 2001

Phylotyping based virulence associated genes and drug susceptibility of Uropathogenic Escherichia coli in urinary tract infection patients. Journal of Microbiology and Biotechnology 2018, 2018

Virulence-associated genes and drug susceptibility patterns of uropathogenic Escherichia coli isolated from patients with urinary tract infection. Infection and Drug Resistance Volume 12: 2039-2047, 2019

Urinary tract infection drives genome instability in uropathogenic Escherichia coli and necessitates translesion synthesis DNA polymerase IV for virulence. Virulence 2(3): 222-232, 2011

Roles of host and bacterial virulence factors in the development of upper urinary tract infection caused by Escherichia coli. American Journal of Kidney Diseases 39(4): 744-752, 2002

Distribution of virulence genes and multiple drug-resistant patterns amongst different phylogenetic groups of uropathogenic Escherichia coli isolated from patients with urinary tract infection. Letters in Applied Microbiology 60(2): 148-154, 2015