+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Role of miRNA-146a in the regulation of the innate immune response and cancer



Role of miRNA-146a in the regulation of the innate immune response and cancer



Biochemical Society Transactions 36(Pt 6): 1211-1215



In mammalian cells, miRNAs (microRNAs) are the most abundant family of small non-coding RNAs that regulate mRNA translation through the RNA interference pathway. In general, it appears that the major function of miRNAs is in development, differentiation and homoeostasis, which is indicated by studies showing aberrant miRNA expression during the development of cancer. Interestingly, changes in the expression of miR-146a have been implicated in both the development of multiple cancers and in the negative regulation of inflammation induced via the innate immune response. Furthermore, miR-146a expression is driven by the transcription factor NF-kappaB (nuclear factor kappaB), which has been implicated as an important causal link between inflammation and carcinogenesis. In the present article, we review the evidence for a role of miR-146a in innate immunity and cancer and assess whether changes in miR-146a might link these two biological responses.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055607993

Download citation: RISBibTeXText

PMID: 19021527

DOI: 10.1042/BST0361211


Related references

MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. Plos One 7(2): E30832, 2012

Expression of miRNA-146a, miRNA-155, IL-2, and TNF-α in inflammatory response to Helicobacter pylori infection associated with cancer progression. Annals of Human Genetics 82(3): 135-142, 2017

Expression of miRNA-155, miRNA-223, miRNA-31, miRNA-21, miRNA-125b, and miRNA-146a in the Inflammatory Pathway of Hidradenitis Suppurativa. Inflammation 40(2): 464-472, 2016

MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response. Frontiers in Immunology 5: 578, 2014

The role of Toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation. Postepy Higieny i Medycyny Doswiadczalnej 60: 52-63, 2006

miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223 expressions in autologous hematopoietic stem cell transplantation and their impact on engraftment. European Journal of Haematology 100(5): 426-435, 2018

Regulation of miRNA-146a and miRNA-150 Levels by Celecoxib in Premalignant Lesions of K14-HPV16 Mice. Anticancer Research 37(6): 2913-2918, 2017

Novel Role of TRPML2 in the Regulation of the Innate Immune Response. Journal of Immunology 195(10): 4922-4932, 2016

Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures. Journal of Inorganic Biochemistry 105(11): 1434-1437, 2012

Role of intracellular degradation system in regulation of innate immune response. Yakugaku Zasshi 134(11): 1157-1164, 2015

Overexpression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patients. Indian Journal of Biochemistry and Biophysics 50(3): 210-214, 2013

Role of Escherichia coli endopeptidases and DD-carboxypeptidases in infection and regulation of innate immune response. Microbes and Infection 2019, 2019

Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis. Plos One 4(8): E6600, 2010

The role of microRNAs in the control of innate immune response in cancer. Journal of the National Cancer Institute 106(10), 2014

Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice 2018: 7295131, 2018