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Role of the growth hormone-insulin-like growth factor-1-insulin system signaling in aging and longevity: evolutional aspect



Role of the growth hormone-insulin-like growth factor-1-insulin system signaling in aging and longevity: evolutional aspect



Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 94(9): 1092-1109



Growth hormone (GH)/ insulin-like growth factor 1 (IGF-1)/ insulin signaling molecules linked to longevity include DAF-2 and insulin-receptor and their homologues in mammals, and to inactivation of corresponding genes followed by increased life span in nematodes, fruit flies, and mice. It is possible that the life-prolonging effect of calorie restriction is due to decreasing IGF-1 levels. A search of pharmacological modulators of life-span-extending mutations in the GH/IGF-1/insulin signaling pathway and mimetic effects of caloric restriction is a priority directions in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer.

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Accession: 055613792

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PMID: 18953996


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