+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of the medial prefrontal cortex in cataplexy



Role of the medial prefrontal cortex in cataplexy



Journal of Neuroscience 33(23): 9743-9751



Narcolepsy is characterized by chronic sleepiness and cataplexy, episodes of profound muscle weakness that are often triggered by strong, positive emotions. Narcolepsy with cataplexy is caused by a loss of orexin (also known as hypocretin) signaling, but almost nothing is known about the neural mechanisms through which positive emotions trigger cataplexy. Using orexin knock-out mice as a model of narcolepsy, we found that palatable foods, especially chocolate, markedly increased cataplexy and activated neurons in the medial prefrontal cortex (mPFC). Reversible suppression of mPFC activity using an engineered chloride channel substantially reduced cataplexy induced by chocolate but did not affect spontaneous cataplexy. In addition, neurons in the mPFC innervated parts of the amygdala and lateral hypothalamus that contain neurons active during cataplexy and that innervate brainstem regions known to regulate motor tone. These observations indicate that the mPFC is a critical site through which positive emotions trigger cataplexy.

(PDF emailed within 0-6 h: $19.90)

Accession: 055614055

Download citation: RISBibTeXText

PMID: 23739971

DOI: 10.1523/JNEUROSCI.0499-13.2013


Related references

The role of the lateral cortico-cortical prefrontal pathway in self-stimulation of the medial prefrontal cortex in the rat. Behavioural Brain Research 31(3): 257-265, 1989

Role of the ventrolateral orbital cortex and medial prefrontal cortex in incentive downshift situations. Behavioural Brain Research 244: 120-129, 2013

Paired associate learning in the rat: Role of hippocampus, medial prefrontal cortex, and parietal cortex. Psychobiology 21(3): 183-192, 1993

Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex. Journal of Neuroscience 27(11): 2948-2957, 2007

Suppression of self stimulation of the medial prefrontal cortex after lesions of sulcal prefrontal cortex or cortical injections of kainic acid. Neuroscience Letters (SUPPL 18): S126, 1984

Monoamine concentrations in rat prefrontal cortex and other mesolimbocortical structures in response to partial neonatal lesions of the medial prefrontal cortex. Brain Research. 601(1-2): 20-27, 1993

Parieto prefrontal connections in the monkey topographic distribution within the prefrontal cortex of sectors connected with the lateral and medial posterior parietal cortex. Society for Neuroscience Abstracts 11(1): 323, 1985

Noradrenergic lesion of the locus coeruleus increases the firing activity of the medial prefrontal cortex pyramidal neurons and the role of alpha2-adrenoceptors in normal and medial forebrain bundle lesioned rats. Brain Research 1324: 64-74, 2010

Role of the medial prefrontal cortex in coping and resilience. Brain Research 1355: 52-60, 2011

Perseveration and the role of dopamine in the medial prefrontal cortex. Society for Neuroscience Abstracts 25(1-2): 1124, 1999

The role of the medial prefrontal cortex in social categorization. Social Cognitive and Affective Neuroscience 9(3): 292-296, 2014

The role of the medial prefrontal cortex in achieving goals. Current Opinion in Neurobiology 14(2): 178-185, 2004

The role of the medial prefrontal cortex in actions and habits. Society for Neuroscience Abstracts 27(1): 1408, 2001

The role of medial prefrontal cortex in attributions of emotion in self and other. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 725 16, 2003