+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of the microbiota and antibiotics in primary sclerosing cholangitis

Role of the microbiota and antibiotics in primary sclerosing cholangitis

Biomed Research International 2013: 389537

Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.

(PDF emailed within 0-6 h: $19.90)

Accession: 055614090

Download citation: RISBibTeXText

PMID: 24232746

DOI: 10.1155/2013/389537

Related references

Healthy Donor Fecal Microbiota Transplantation for Recurrent Bacterial Cholangitis in Primary Sclerosing Cholangitis - A Single Case Report. Journal of Clinical and Translational Hepatology 6(4): 438-441, 2019

The "gut microbiota" hypothesis in primary sclerosing cholangitis. Annals of Translational Medicine 4(24): 512, 2017

Intestinal microbiota in primary sclerosing cholangitis. Current Opinion in Gastroenterology 33(2): 85-92, 2016

The features of mucosa-associated microbiota in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics 43(7): 790-801, 2016

High prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis. European Journal of Internal Medicine 20(2): 190-196, 2009

Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis. Clinical Gastroenterology and Hepatology 6(8): 939-943, 2008

Natural history of primary sclerosing cholangitis A longterm follow-up study of 394 European primary sclerosing cholangitis patients. Journal of Hepatology 32(Supplement 2): 32, 2000

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis. Gut 2019, 2019

Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut 66(4): 753-754, 2016

Ursodiol for primary sclerosing cholangitis. Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group. New England Journal of Medicine 336(10): 691-695, 1997

Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World Journal of Gastroenterology 23(25): 4548-4558, 2018

Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis. Journal of Crohn's and Colitis 10(3): 330-337, 2016

Antibiotics for the treatment of primary sclerosing cholangitis. American Journal of Therapeutics 18(3): 261-265, 2012

Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies. Scandinavian Journal of Gastroenterology 49(8): 901-908, 2015

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. United European Gastroenterology Journal 6(1): 112-122, 2018