+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Role of the opioid system in incentive downshift situations

Role of the opioid system in incentive downshift situations

Neurobiology of Learning and Memory 92(3): 439-450

Previous research has shown that opioid blockage enhances consummatory successive negative contrast (cSNC)-a suppression of consummatory behavior following a downshift from 32% to 4% sucrose solution. In Experiment 1, administration of the nonselective opioid receptor antagonist naloxone (2 mg/kg, ip) distorted the comparison between expected and received incentives. The results of Experiment 2 discarded the alternative that naloxone enhances cSNC by inducing a conditioned taste aversion. The results of Experiments 3a-3c provided no evidence that opioid administration after the first downshift trial modulated subsequent consummatory performance. The opioids tested included naloxone (2mg/kg, ip), the delta-opioid receptor selective antagonist naltrindole (1 mg/kg, ip), and the delta-opioid receptor selective agonist DPDPE (24 microg/kg, ip). The selected doses have proven in earlier experiments to be effective when administered before training. Experiments 4-5 failed to uncover any effects of posttraining opioid blockage with naloxone in an appetitive extinction task (autoshaping with lever-food pairings). These results add to our previous understanding of opioid function in situations involving incentive downshifts, suggesting a role in the comparison process that triggers cSNC, but no apparent function in memory consolidation related to the downshift event.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055614226

Download citation: RISBibTeXText

PMID: 19531382

DOI: 10.1016/j.nlm.2009.06.003

Related references

Role of the ventrolateral orbital cortex and medial prefrontal cortex in incentive downshift situations. Behavioural Brain Research 244: 120-129, 2013

Scaling relative incentive value: different adjustments to incentive downshift in pigeons and rats. Behavioural Processes 79(3): 182-188, 2008

Posttrial d-cycloserine enhances the emotional memory of an incentive downshift event. Behavioural Brain Research 223(2): 348-355, 2011

Consummatory suppression due to incentive downshift is not a consequence of enhanced search behavior. Behavioural Processes 98: 69-71, 2014

Long-lasting effects of perinatal asphyxia on exploration, memory and incentive downshift. International Journal of Developmental Neuroscience 29(6): 609-619, 2012

Posttrial corticosterone administration enhances the effects of incentive downshift: exploring the boundaries of this effect. Behavioral Neuroscience 123(1): 137-144, 2009

Effects of testosterone administration and gonadectomy on incentive downshift and open field activity in rats. Physiology & Behavior 106(5): 657-663, 2012

Impairment of recovery from incentive downshift after lesions of the anterior cingulate cortex: emotional or cognitive deficits?. Behavioral Neuroscience 125(6): 988-995, 2012

Emotional reactivity to incentive downshift as a correlated response to selection of high and low alcohol preferring mice and an influencing factor on ethanol intake. Alcohol 49(7): 657-664, 2016

The role of incentive design, incentive value, communications strategy, and worksite culture on health risk assessment participation. American Journal of Health Promotion 23(5): 343-352, 2009

Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity. Neuroscience 75(3): 917-926, 1996

The role of behavioral economic incentive design and demographic characteristics in financial incentive-based approaches to changing health behaviors: a meta-analysis. American Journal of Health Promotion 29(5): 314-323, 2015

Cardiovascular effects of active coping behavior in mental and social stress situations during various incentive conditions. Zeitschrift für Experimentelle Psychologie 43(2): 256-278, 1996

Inhibitory Processes for Critical Situations - The Role of n-2 Task Repetition Costs in Human Multitasking Situations. Frontiers in Physiology 3: 159-159, 2012

The role of opioid prescription in incident opioid abuse and dependence among individuals with chronic noncancer pain: the role of opioid prescription. Clinical Journal of Pain 30(7): 557-564, 2015