+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of the promoter polymorphism IL-6 -174G/C in dermatomyositis and systemic lupus erythematosus



Role of the promoter polymorphism IL-6 -174G/C in dermatomyositis and systemic lupus erythematosus



Biomed Research International 2013: 315365



The promoter polymorphism -174G/C within the interleukin-6 gene (IL-6) has been reported to have a functional importance through the modulation of IL-6 gene expression in vitro and in vivo. IL-6 is thought to play an important role in autoimmune diseases and the effect of its receptor inhibitor-tocilizumab-has been recently studied. The aim of this case-control study was to investigate the association between the interleukin-6 -174G/C single nucleotide polymorphism and the susceptibility to dermatomyositis (DM) and systemic lupus erythematosus (SLE) in Bulgarian patients. Altogether, 87 patients-52 with SLE and 35 with DM-as well as 80 unrelated healthy controls were included in this study. All of them were analyzed by restriction fragment length polymorphism analysis (RFLP). The GG genotype and the G allele appeared to be associated with SLE, especially in women. None of the genotypes showed an association with DM. However, the G allele appeared to be associated with muscle weakness and it is a risk factor for elevated muscle enzymes. Our results indicate that IL-6 -174G/C polymorphism might be associated with the susceptibility to SLE especially in women. Although it is not associated with DM, it seems that IL-6 -174G/C polymorphism could modulate some clinical features in the autoimmune myopathies.

(PDF emailed within 0-6 h: $19.90)

Accession: 055614386

Download citation: RISBibTeXText

PMID: 24106699

DOI: 10.1155/2013/315365


Related references

IL-6 promoter polymorphism (174G/C) and systemic lupus erythematosus. Comparative Clinical Pathology 21(5): 975-979, 2012

IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus. Dermatology Research and Practice 2014: 953597, 2014

The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus. Journal of Biological Chemistry 282(3): 1738-1746, 2006

The role of upstream stimulatory factor 1 in the transcriptional regulation of the human TBX21 promoter mediated by the T-1514C polymorphism associated with systemic lupus erythematosus. Immunogenetics 64(5): 361-370, 2012

Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis. Modern Rheumatology 20(5): 466-470, 2011

Relationship between MCP-1 promoter -2518 A/G gene polymorphism (rs1024611) and systemic lupus erythematosus/lupus nephritis. Journal of Receptor and Signal Transduction Research 35(1): 85-93, 2016

Clinical significance of serum TNF? and -38 G/A promoter polymorphism and serum Il-6 and -174 G/C promoter polymorphism in systemic lupus erythematosus patients. The Egyptian Rheumatologist 34(3): 119-125, 2012

Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at -1149G/T. Journal of Immunology Research 2015: 435658, 2016

Association of interleukin-6 promoter polymorphism (-174 G/C) with systemic lupus erythematosus. Clinical Rheumatology 30(6): 867-868, 2011

MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus. Tissue Antigens 58(5): 335-338, 2002

Interleukin-6 promoter polymorphism in German patients with systemic lupus erythematosus. Arthritis & Rheumatism 42(9 SUPPL ): S234, Sept, 1999

Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosus. Journal of Rheumatology 28(9): 2008-2011, 2001

A functional polymorphism in fas (CD95/APO-1) gene promoter associated with systemic lupus erythematosus. Journal of Rheumatology 29(6): 1183-1188, 2002

Influence of MX1 promoter rs2071430 G/T polymorphism on susceptibility to systemic lupus erythematosus. Clinical Rheumatology 35(3): 623-629, 2016

Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research 2016: 3042726, 2017