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Role of the transcription factor NFIC in odontoblast gene expression

Role of the transcription factor NFIC in odontoblast gene expression

Journal of the California Dental Association 37(12): 875-881

The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.

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Accession: 055614624

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PMID: 20066876

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