+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of thrombophilia in vascular access thrombosis among chronic hemodialysis patients in Tunisia



Role of thrombophilia in vascular access thrombosis among chronic hemodialysis patients in Tunisia



Therapeutic Apheresis and Dialysis 15(1): 40-43



Vascular access thrombosis represents a serious and common problem in hemodialysis patients. Therefore, identification of relevant thrombotic risk factors could lead to an improved antithrombotic therapy. This case control study was performed to evaluate the relationship between some thrombophilias and vascular access thrombosis in hemodialysis patients. Seventy-eight patients undergoing dialysis (between May 2007 and September 2009) were selected as subjects. This sample was divided into two groups; a case group of 28 patients who had sustained one or more thrombotic events that resulted in vascular access failure and a control group of 50 patients, who had never had a thrombotic occlusion of a functioning permanent dialysis access. Antithrombin, protein C and protein S levels were measured. Also, both groups were tested for the factor V Leiden mutation, the prothrombin G20210A mutation, the methylene tetrahydrofolate reductase C677T and A1298C mutations. Among genetic mutations of factor V Leiden, prothrombin G20210A and methylene tetrahydrofolate reductase genes, the C677T methylene tetrahydrofolate reductase mutation was the only significant genetic cause of vascular access thrombosis (P=0.005). Our data demonstrated a significantly increased risk of vascular access thrombosis in carriers of the C677T methylene tetrahydrofolate reductase mutation.

(PDF emailed within 0-6 h: $19.90)

Accession: 055614835

Download citation: RISBibTeXText

PMID: 21272251

DOI: 10.1111/j.1744-9987.2010.00848.x


Related references

Thrombophilia and the risk for hemodialysis vascular access thrombosis. Journal of the American Society of Nephrology 16(4): 1108-1114, 2005

A case report of recurrent vascular access thrombosis in a hemodialysis patient reveals combined acquired and inherited thrombophilia. Therapeutic Apheresis and Dialysis 12(2): 190-192, 2008

IgM-anticardiolipin antibody and vascular access thrombosis in chronic hemodialysis patients. Renal Failure 27(1): 25-30, 2005

Atrial fibrillation linked to vascular access thrombosis in chronic hemodialysis patients. Journal of Atherosclerosis and Thrombosis 18(6): 448-453, 2011

Role of Genetic Factors in Vascular Access Thrombosis in Hemodialysis Patients. Hemodialysis International 8(1): 81-82, 2004

Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis. Nephron 92(4): 957-958, 2002

Hyperhomocysteinaemia and vascular access thrombosis among chronic hemodialysis patients in Taiwan: a retrospective study. International Journal of Clinical Practice 60(12): 1596-1599, 2006

Use of enoxaparin to diminish the incidence of vascular access stenosis/thrombosis in chronic hemodialysis patients. International Urology and Nephrology 43(2): 499-505, 2011

Role of genetic mutations in vascular access thrombosis among hemodialysis patients waiting for renal transplantation. Transplantation Proceedings 34(6): 2030-2032, 2002

Role of the hyperhomocysteinemia and coagulation-fibrinolytic system activity status in vascular access thrombosis in hemodialysis patients. Nephrology Dialysis Transplantation 15(9): A190, September, 2000

Recombinant streptokinase treatment of thrombosis of the permanent vascular access in chronic renal insufficiency patients treated with periodic hemodialysis. Biotecnologia Aplicada 12(3): 195-196, 1995

The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. Anadolu Kardiyoloji Dergisi 14(3): 239-243, 2015

Variable flow Doppler vascular access blood flow predicts vascular access thrombosis in hemodialysis patients with PTEE grafts. Journal of the American Society of Nephrology 12(Program and Abstract Issue): 296A-297A, September, 2001

Hyperhomocysteinemia and vascular access thrombosis in chronic hemodialysis Is there an association?. Journal of the American Society of Nephrology 11(Program and Abstract Issue): 282A, September, 2000

No association between hyperhomocysteinemia and vascular access thrombosis in chronic hemodialysis. Journal of Vascular Access 4(1): 14-20, 2003