+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation



Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation



Thrombosis Research 127 Suppl 3: S43-S46



Bad pregnancy outcomes have been associated with increased activation of the coagulation cascade and inflammation, in particular the activation of the complement cascade. Recent studies have suggested that inflammatory processes modulate thrombogenic pathways and vice versa. We studied the cross-talk between the coagulation and the complement cascade in the pathogenesis of recurrent miscarriages and preeclampsia in mice. We identified tissue factor (TF) as a crucial mediator of fetal and placental damage in mouse models of recurrent miscarriages and preeclampsia. Increased TF expression increases the release of reactive oxygen species and antiangiogenic molecules from inflammatory cells inducing trophoblast damage and bad pregnancy outcomes. We also demonstrated that pravastatin, by downregulating TF expression, prevents miscarriages and the onset of preeclampsia in mice.

(PDF emailed within 0-6 h: $19.90)

Accession: 055614895

Download citation: RISBibTeXText

PMID: 21262438

DOI: 10.1016/S0049-3848(11)70012-3


Related references

The role of tissue factor and tissue factor pathway inhibitor in blood coagulation and in thrombotic complications. Kardiologia Polska 68(10): 1158-1162, 2011

Possibility of Coagulation System Activation Determination with Tissue Factor in Pregnancy Complications. Clinical Laboratory 62(10): 1851-1856, 2017

Tissue factor and tissue factor pathway inhibitor: a potential role in pregnancy and obstetric vascular complications?. Clinica Chimica Acta; International Journal of Clinical Chemistry 372(1-2): 43-46, 2006

ID: 352 Role of Tissue Factor, Coagulation Proteases and PARs in Inflammation. Journal of Thrombosis and Haemostasis 4(S1): 64-64, 2006

Role of tissue factor in pregnancy complications. Journal of Reproductive Immunology 86(1): 22-0, 2010

Coagulation, inflammation, and pregnancy complications. Lancet 363(9403): 96-97, 2004

The role of coagulation-fibrinolytic system in diabetic vascular complications. Part 1: Urine factor excretion in diabetics and its role in the intraglomerular coagulation. Nihon Ketsueki Gakkai Zasshi 43(4): 715-722, 1980

The role of coagulation fibrinolytic system in diabetic vascular complications 1. urine factor excretion in diabetics and its role in the intra glomerular coagulation. Acta Haematologica Japonica 43(4): 715-722, 1980

No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats. Critical Care Medicine 34(10): 2646-2650, 2006

Tissue factor expression at the site of inflammation: a cross-talk between inflammation and the blood coagulation system. Rinsho Byori. Japanese Journal of Clinical Pathology 52(4): 342-349, 2004

Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit. Frontiers in Bioscience 11: 256-271, 2005

Role of tissue factor in thrombosis. Coagulation-inflammation- thrombosis circuit. Frontiers in Bioscience 11: 256-271, 2006

Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver. Canadian Journal of Physiology and Pharmacology 91(11): 867-872, 2014

Tissue factor accelerates the activation of coagulation factor viii the role of a bifunctional coagulation cofactor. Thrombosis Research 40(3): 351-358, 1985

The Role of Gap Junction-Mediated Endothelial Cell-Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation. International Journal of Molecular Sciences 18(11), 2017