+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense

Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense

Biological Chemistry 389(12): 1513-1522

Human tissue kallikrein-related peptidases (KLKs) are 15 hormonally regulated genes on chromosome 19q13.4 encoding secreted serine proteases. Many KLKs are expressed throughout the female reproductive system and found in cervico-vaginal fluid (CVF). Immunohistochemistry was performed to determine KLK localization in the female reproductive system (fallopian tube, endometrium, cervix and vagina tissues). KLK levels were measured in CVF and saliva over the menstrual cycle to study whether KLKs are regulated by hormonal changes during the cycle. In vitro cleavage analysis was performed to establish whether KLKs may play a role in vaginal epithelial desquamation, mucus remodeling or processing of antimicrobial proteins. KLKs were localized in the glandular epithelium of the fallopian tubes and endometrium, the cervical mucus-secreting epithelium and vaginal stratified squamous epithelium. KLK levels peaked in CVF and saliva after ovulation. In vitro cleavage analysis confirmed KLKs 5 and 12 as capable of digesting desmoglein and desmocollin adhesion proteins and cervical mucin proteins 4 and 5B. KLK5 can digest defensin-1alpha, suggesting it may aid in cervico-vaginal host defense. We provide evidence of potential physiological roles for KLKs in cervico-vaginal physiology: in desquamation of vaginal epithelial cells, remodeling of cervical mucus and processing of antimicrobial proteins.

(PDF emailed within 0-6 h: $19.90)

Accession: 055614903

Download citation: RISBibTeXText

PMID: 18844451

DOI: 10.1515/BC.2008.171

Related references

A potential role for tissue kallikrein-related peptidases in human cervico-vaginal physiology. Biological Chemistry 389(6): 681-688, 2008

Overview of tissue kallikrein and kallikrein-related peptidases in breast cancer. Biological Chemistry 399(9): 937-957, 2018

The Role of Kallikrein-Related Peptidases in Atopic Dermatitis. Acta Medica Okayama 73(1): 1-6, 2019

Prognostic significance of human tissue kallikrein-related peptidases 6 and 10 in gastric cancer. Biological Chemistry 395(9): 1087-1093, 2015

Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer. Tumour Biology 37(1): 437-446, 2017

Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma. Human Pathology 46(4): 541-548, 2015

Prognostic value and biological role of the kallikrein-related peptidases in human malignancies. Future Oncology 6(2): 269-285, 2010

Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases. Biological Chemistry 395(9): 977-990, 2015

Kallikrein-related peptidases in cancers of gastrointestinal tract: an inside view of their role and clinical significance. Journal of B.U.On. 19(1): 53-59, 2014

The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition. Biological Chemistry 387(6): 707-714, 2006

Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. American Journal of Cancer Research 8(9): 1856-1864, 2018

The role of mucus in intestinal host defense developmental differences in composition and binding to cholera toxin. Pediatric Research 20(4 PART 2): 249A, 1986

Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis. Journal of Dermatological Science 49(1): 7-19, 2007

Cervical mucus inhibits microbial growth A host defense mechanism to prevent ascending infection in pregnant and non-pregnant women. American Journal of Obstetrics & Gynecology 168(1 PART 2): 312, 1993

Kallikrein-related peptidases. Cellular and Molecular Life Sciences 65(13): 2019-2038, 2008