+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of topical drugs in treatment of oral mucosal diseases. A literature review



Role of topical drugs in treatment of oral mucosal diseases. A literature review



New York State Dental Journal 79(6): 58-64



Few topical formulations have been designed specifically to treat oral mucosal diseases. Local drug delivery may provide a more targeted and efficient option than systemic delivery for diseases of the oral mucosa. The permeability to the topical drugs differs according to the thickness of the epithelium and the extent of keratinization. The loss of the permeability barrier in the oral mucosa, due to ulceration or erosion, leads to rapid diffusion of the drug into tissues as compared to the intact areas of the mucosa. Oral mucosal delivery has the potential to treat many different conditions and diseases, such as oral cancer, mucositis, lichen planus, herpes simplex, candidiasis, recurrent aphthous stomatitis, vesiculo-bullous diseases, neuropathic pain and salivary dysfunction. Each therapy requires distinct penetration and drug retention profiles in order to optimize treatment and minimize side effects. In this paper, topical medications are discussed, as these are advantageous for the treatment of oral mucosal lesions with fewer side effects.

(PDF emailed within 1 workday: $29.90)

Accession: 055614973

Download citation: RISBibTeXText

PMID: 24600767


Related references

Immunopathology of oral mucosal ulcerative, desquamative, and bullous diseases. Selective review of the literature. Oral Surgery, Oral Medicine, and Oral Pathology 77(6): 555-571, 1994

The implant-mucosal interface and its role in the long-term success of endosseous oral implants: a review of the literature. International Journal of Prosthodontics 11(5): 421-432, 1999

Role of oral Polypodium leucotomos extract in dermatologic diseases: a review of the literature. Journal of Drugs in Dermatology 13(2): 148-153, 2014

Primary mucosal sinonasal melanoma-Case report and review of the literature. The role of complex treatment-surgery and adjuvant radiotherapy. Reports of Practical Oncology and RadioTherapy 16(1): 40-43, 2010

Betel quid chewing, oral cancer and other oral mucosal diseases in Vietnam: a review. Journal of Oral Pathology & Medicine 37(9): 511-514, 2008

Topical immunomodulators for management of oral mucosal conditions, a systematic review; part I: calcineurin inhibitors. Expert Opinion on Emerging Drugs 15(4): 713-726, 2011

Topical immunomodulators for management of oral mucosal conditions, a systematic review; Part II: miscellaneous agents. Expert Opinion on Emerging Drugs 16(1): 183-202, 2011

Treatment of oral mucosal diseases: part V. Current development in diagnosis and treatment of oral candidiasis. Zhonghua Kou Qiang Yi Xue Za Zhi 41(12): 767-769, 2007

Treatment of oral mucosal diseases: Part I. Diagnosis and treatment of oral leukoplakia, erythroplakia and melanoplakia. Zhonghua Kou Qiang Yi Xue Za Zhi 41(8): 502-505, 2006

Topical liposome drugs to come: what the patent literature tells us. A review. Journal of the American Academy of Dermatology 25(6 Pt 1): 1068-1071, 1991

Contact dermatitis to topical acne drugs: a review of the literature. Dermatologic Therapy 28(5): 323-329, 2016

Treatment of oral mucosal diseases: part IV. Diagnosis and treatment of oral lichen planus. Zhonghua Kou Qiang Yi Xue Za Zhi 41(11): 697-699, 2007

Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus. Dermatology 210(3): 229-232, 2005

Analysis of effect of non-steroidal anti-inflammatory drugs on teeth and oral tissues during orthodontic treatment. Report based on literature review. Acta Poloniae Pharmaceutica 70(3): 573-577, 2013

Topical treatment of selected skin and mucosal diseases with betamethasone 17-valerate. Polski Tygodnik Lekarski 28(46): 1822-1824, 1973