EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Roles of chromatin remodelers in maintenance mechanisms of multipotency of mouse trunk neural crest cells in the formation of neural crest-derived stem cells



Roles of chromatin remodelers in maintenance mechanisms of multipotency of mouse trunk neural crest cells in the formation of neural crest-derived stem cells



Mechanisms of Development 133: 126-145



We analyzed roles of two chromatin remodelers, Chromodomain Helicase DNA-binding protein 7 (CHD7) and SWItch/Sucrose NonFermentable-B (SWI/SNF-B), and Bone Morphogenetic Protein (BMP)/Wnt signaling in the maintenance of the multipotency of mouse trunk neural crest cells, leading to the formation of mouse neural crest-derived stem cells (mouse NCSCs). CHD7 was expressed in the undifferentiated neural crest cells and in the dorsal root ganglia (DRG) and sciatic nerve, typical tissues containing NCSCs. BMP/Wnt signaling stimulated the expression of CHD7 and participated in maintaining the multipotency of neural crest cells. Furthermore, the promotion of CHD7 expression maintained the multipotency of these cells. The inhibition of CHD7 and SWI/SNF-B expression significantly suppressed the maintenance of the multipotency of these cells. In addition, BMP/Wnt treatment promoted CHD7 expression and caused the increase of the percentage of multipotent cells in DRG. Thus, the present data suggest that the chromatin remodelers as well as BMP/Wnt signaling play essential roles in the maintenance of the multipotency of mouse trunk neural crest cells and in the formation of mouse NCSCs.

(PDF emailed within 0-6 h: $19.90)

Accession: 055616880

Download citation: RISBibTeXText

PMID: 24836203

DOI: 10.1016/j.mod.2014.05.001



Related references

Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell 2(4): 392-403, 2008

Extended multipotency of neural crest cells and neural crest-derived cells. Current Topics in Developmental Biology 111: 69-95, 2015

Piscine neural crest development: neural crest formation and behavior of neural crest cells in Xiphophorus and Oryzias. GSF-Bericht. 1992( ); 7: 149-160, 1993

Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. Journal of Anatomy 222(1): 19-31, 2013

Effects of ultraviolet light on melanocyte differentiation: studies with mouse neural crest cells and neural crest-derived cell lines. Pigment Cell Research 17(2): 150-157, 2004

Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crest. Developmental Biology 324(1): 152-160, 2008

Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling. Biomaterials 167: 153-167, 2018

Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling. Biomaterials 167: 153-167, 2018

At the border of pluri- and multipotency: the neural crest stem cells. Orvosi Hetilap 156(42): 1683-1694, 2016

Anorectal neural crest derived cell behavior after the migration of vagal neural crest derived cells is surgically disrupted: implications for the etiology of Hirschsprung's disease. Pediatric Surgery International 29(1): 9-12, 2013

Neural crest-derived cells sustain their multipotency even after entry into their target tissues. Developmental Dynamics 243(3): 368-380, 2014

The neural crest stem cells: control of neural crest cell fate and plasticity by endothelin-3. Anais Da Academia Brasileira de Ciencias 73(4): 533-545, 2001

The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube. Developmental Biology 200(2): 234-246, 1998

SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron 38(1): 17-31, April 10, 2003

Effects of low-intensity pulsed ultrasound on cell viability, proliferation and neural differentiation of induced pluripotent stem cells-derived neural crest stem cells. Biotechnology Letters 35(12): 2201-2212, 2014