+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Scleroderma renal crisis, still a life-threatening complication



Scleroderma renal crisis, still a life-threatening complication



Annals of the new York Academy of Sciences 1108: 249-258



Scleroderma renal crisis (SRC) is a major complication in patients with systemic sclerosis (SSc). SRC occurs during the first 4 years of disease evolution in more than 75% of the cases, almost exclusively in patients with diffuse SSc. Other risk factors, including preceding corticosteroid therapy, have been associated with an increased occurrence of SRC. Prior to the late 1970s, SRC was a major cause of death in SSc patients. However, the prognosis has dramatically improved with the introduction of angiotensin-converting enzyme inhibitors. Thus, prompt diagnosis and early initiation of angiotensin-converting enzyme inhibitors therapy will improve the outcome. Nevertheless, additional antihypertensive treatments are often needed. Quite a large proportion of patients require dialysis, although this therapy may be stopped in approximately one-third of patients. Patients remaining on dialysis after 2 years can be proposed for a renal transplantation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055667977

Download citation: RISBibTeXText

PMID: 17893990

DOI: 10.1196/annals.1422.027


Related references

Scleroderma renal crisis is still a life-threatening syndrome. Renal Failure 18(4): 567-574, 1996

Scleroderma renal crisis as a possible complication of cyclosporin A withdrawal. Clinical Rheumatology 13(1): 126-128, 1994

Exposure to ACE inhibitors prior to the onset of scleroderma renal crisis-results from the International Scleroderma Renal Crisis Survey. Seminars in Arthritis and Rheumatism 43(5): 666-672, 2014

Scleroderma renal crisis: a rare but severe complication of systemic sclerosis. Clinical Reviews in Allergy and Immunology 40(2): 84-91, 2011

Scleroderma Renal Crisis: Risk Factors for an Increasingly Rare Organ Complication. Journal of Rheumatology 2019:, 2019

Intriguing presentation of scleroderma renal crisis (scleroderma renal crisis sine scleroderma sine hypertension). Nephrology Dialysis Transplantation 13(11): 2953-2956, 1998

Renal artery pseudoaneurysm of infectious etiology: a life-threatening complication after renal transplantation. Urology 68(3): 668-669, 2006

Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. Annals of Hematology 87(6): 499-500, 2008

Myocardial aspergillosis A life-threatening complication in renal transplantation. Kidney & Blood Pressure Research 21(2-4): 156, 1998

Haemophagocytic syndrome--a life-threatening complication of renal transplantation. Nephrology Dialysis Transplantation 24(9): 2623-2627, 2009

Endotracheal metastases in renal cell carcinoma: A life-threatening but treatable complication. European Journal of Internal Medicine 18(2): 161-163, 2007

Spontaneous hypoglycemia associated with chronic renal failure--a preventable life-threatening complication. Acta Medica Croatica 48(4-5): 207-210, 1994

Hemorrhage as a life-threatening complication after valve replacement in end-stage renal disease patients. General Thoracic and Cardiovascular Surgery 63(7): 386-394, 2015

Life-threatening hyperkalemia: a complication of spironolactone for heart failure in a patient with renal insufficiency. Anesthesia and Analgesia 95(1): 39-41 Table of Contents, 2002

Life-threatening complication after extracorporeal shock wave lithotripsy for a renal stone: a hepatic subcapsular hematoma. Korean Journal of Urology 51(3): 212-215, 2010