+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Screening and functional microarray analysis of differentially expressed genes related to osteoporosis



Screening and functional microarray analysis of differentially expressed genes related to osteoporosis



Genetics and Molecular Research 13(2): 3228-3236



We searched for key genes that could accurately predict bone mineral density. The gene expression profile GSE7429 was downloaded from the Gene Expression Omnibus database, which includes 20 samples, 10 with high and 10 with low bone mineral density. The differentially expressed genes (DEGs) were identified with packages in R language. Further, BLASTX was used to obtain COG function classifications of all the DEGs. The GOTM software was used to find DEGs enriched modules. The functions of genes in the modules was also predicted with the software GENECODIS. Three hundred and three genes were identified as DEGs by comparing high and low bone mineral density samples; the selected genes were mapped to 14 modules collected in PPID. Genes VDR, ESR1, and NRIP1, located in the same module, were significantly enriched in intracellular receptor-mediated signaling biological processes. We conclude that the genes VDR, ESR1, NRIP1 in B cells have a close relationship with bone mineral density. The expression patterns of these genes could be used to determine osteoprotegerin function and for early diagnosis and prevention of low bone mineral density.

(PDF emailed within 0-6 h: $19.90)

Accession: 055670109

Download citation: RISBibTeXText

PMID: 24841655

DOI: 10.4238/2014.April.25.8


Related references

Screening of differentially expressed genes related to bladder cancer and functional analysis with DNA microarray. Asian Pacific Journal of Cancer Prevention 14(8): 4553-4557, 2014

Screening of differentially expressed genes related to ischemic stroke and functional analysis with DNA microarray. European Review for Medical and Pharmacological Sciences 18(8): 1181-1188, 2015

DNA microarray-based screening of differentially expressed genes related to acute lung injury and functional analysis. European Review for Medical and Pharmacological Sciences 17(8): 1044-1050, 2013

Screening of differentially expressed genes associated with human glioblastoma and functional analysis using a DNA microarray. Molecular Medicine Reports 12(2): 1991-1996, 2016

Screening and functional analysis of differentially expressed genes in chronic glomerulonephritis by whole genome microarray. Gene 589(1): 72-80, 2017

Identification and functional analysis of differentially expressed genes related to obesity using DNA microarray. Genetics and Molecular Research 13(1): 64-72, 2014

Screening of osteoprotegerin-related feature genes in osteoporosis and functional analysis with DNA microarray. European Journal of Medical Research 18: 15, 2013

Screening of differentially expressed genes related to laterally spreading tumor by cDNA microarray. Di 1 Jun Yi Da Xue Xue Bao 24(9): 1023-1025, 2004

Screening of differentially expressed genes related to esophageal squamous cell carcinoma and functional analysis with DNA microarrays. International Journal of Oncology 44(4): 1163-1170, 2014

Screening of differentially expressed genes associated with Kawasaki disease by microarray analysis. Experimental and Therapeutic Medicine 14(4): 3159-3164, 2017

Screening of differentially expressed genes related to severe sepsis induced by multiple trauma with DNA microarray. European Review for Medical and Pharmacological Sciences 18(5): 734-739, 2016

Screening of differentially expressed genes associated with non-union skeletal fractures and analysis with a DNA microarray. Experimental and Therapeutic Medicine 7(3): 609-614, 2014

Functional analysis of differentially expressed genes associated with glaucoma from DNA microarray data. Genetics and Molecular Research 13(4): 9421-9428, 2015

Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes. Molecular Human Reproduction 8(7): 674-680, 2002

Screening for differentially expressed genes between left- and right-sided colon carcinoma by microarray analysis. Oncology Letters 6(2): 353-358, 2013