+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Semiparametric odds ratio model for case-control and matched case-control designs

Semiparametric odds ratio model for case-control and matched case-control designs

Statistics in Medicine 32(18): 3126-3142

ISSN/ISBN: 0277-6715

PMID: 23307592

DOI: 10.1002/sim.5742

We propose a semiparametric odds ratio model that extends Umbach and Weinberg's approach to exploiting gene-environment association model for efficiency gains in case-control designs to both discrete and continuous data. We directly model the gene-environment association in the control population to avoid estimating the intercept in the disease risk model, which is inherently difficult because of the scarcity of information on the parameter with the sampling designs. We propose a novel permutation-based approach to eliminate the high-dimensional nuisance parameters in the matched case-control design. The proposed approach reduces to the conditional logistic regression when the model for the gene-environment association is unrestricted. Simulation studies demonstrate good performance of the proposed approach. We apply the proposed approach to a study of gene-environment interaction on coronary artery disease.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055709553

Download citation: RISBibTeXText

Related references

Planning the size of a matched case-control study for estimation of the odds ratio. American Journal of Epidemiology 122(2): 345-347, 1985

A simple method for estimating the odds ratio in matched case-control studies with incomplete paired data. Statistics in Medicine 31(27): 3299-3312, 2012

Estimators of odds ratio regression parameters in matched case-control studies with covariate measurement error. Journal of the American Statistical Association 90(431): 1075-1084, 1995

Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio. Journal of Clinical Epidemiology 43(1): 55-59, 1990

Semiparametric isotonic regression analysis for risk assessment under nested case-control and case-cohort designs. Statistical Methods in Medical Research 29(8): 2328-2343, 2020

Odds ratio of risk factors for oral submucous fibrosis in a case control model. British Journal of Oral and Maxillofacial Surgery 51(7): E169-E173, 2013

Factors influencing the optimal control-to-case ratio in matched case-control studies. American Journal of Epidemiology 149(2): 195-197, 1999

Semiparametric Regression Splines in Matched Case-Control Studies. Biometrics 59(4): 58-69, 2003

Semiparametric regression splines in matched case-control studies. Biometrics 59(4): 1158-1169, 2003

A new semiparametric procedure for matched case-control studies with missing covariates. Journal of Nonparametric Statistics 21(7): 889-905, 2009

Semiparametric Inference in Matched Case-Control Studies with Missing Covariate Data. Biometrika 89(4): 905-916, 2002

Semiparametric Bayesian analysis of matched case-control studies with missing exposure. Journal of the American Statistical Association 100(470): 591-601, 2005

Bayesian semiparametric modeling for matched case-control studies with multiple disease states. Biometrics 60(1): 41-49, 2004

Semiparametric tests for identifying differentially methylated loci with case-control designs using Illumina arrays. Genetic Epidemiology 38(1): 42-50, 2014

Estimation of Odds Ratios from Matched Case-Control Studies with Incomplete Data. Biometrical Journal 33(6): 673-682, 1991