+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sentinel lymph node biopsy or nodal observation in melanoma: study of an Italian series



Sentinel lymph node biopsy or nodal observation in melanoma: study of an Italian series



Giornale Italiano di Dermatologia E Venereologia 148(3): 299-305



The purpose of this study was to investigate the disease-free time (DFT) and overall survival (OS) of patients with intermediate or high-risk cutaneous melanoma who were treated with conventional surgery alone, and to compare them with that of a second group of patients who were treated with surgery and SLN biopsy. A retrospective, single-centre study was performed at the Department of Dermatology of the "M. Bufalini" Hospital, Cesena, Italy based on data collected between January 1990 and December 2007. A total of 757 consecutive patients with stage I-II melanoma were identified: the former group (control group), treated with conventional surgery, was composed of 224 patients; the latter, treated with surgery and SLN biopsy (SLN biopsy group), was formed of 529 patients. The 5-year disease free time (DFT) rate, estimated with Kaplan-Meyer, was 73.9% (95% CI: 67.5-79.2) in the control group, and 82.2% (95% CI: 78.6-85.3) in the SLN biopsy group. Although the DFT rate was significantly higher in the SLN group than in the control group in univariate analyses (P=0.004), this gain was lost in multivariate analysis (P=0.2). The 5-year overall survival (OS) rate was 88.4% (95% CI: 83.2-92.1) for the control group, and 87.9% (95% CI: 84.6-90.4) for the SLN biopsy group. Statistical comparison of specific OS was not statistically significant (P=0.93). On the basis of our follow-up data, we found that patients who underwent SLN biopsy technique experienced a reduction in the proportion of lymph nodal relapse, but DFT and OS were statistically equivalent between the two groups.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055715338

Download citation: RISBibTeXText

PMID: 23670067


Related references

Sentinel Lymph Node Biopsy or Nodal Observation in Melanoma: a Prospective Study of Patient Choices. Yearbook of Dermatology and Dermatologic Surgery 2012: 444-445, 2012

Sentinel lymph node biopsy or nodal observation in melanoma: a prospective study of patient choices. Dermatologic Surgery 37(2): 199-206, 2011

Sentinel-node biopsy or nodal observation in melanoma. New England Journal of Medicine 355(13): 1307-1317, 2006

Sentinel-node biopsy or nodal observation in melanoma. Current Oncology Reports 9(5): 401, 2007

Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients. Medicine 94(36): E1433, 2015

Prediction of Non-sentinel Node Status in Patients with Melanoma and Positive Sentinel Node Biopsy: An Italian Melanoma Intergroup (IMI) Study. Annals of Surgical Oncology 25(1): 271-279, 2018

Sentinel lymph node biopsy in cutaneous melanoma: a study of 45 cases in a series of 142 melanomas. Medicina Clinica 123(16): 635, 2004

Sentinel lymph node biopsy versus observation in thick melanoma: A multicenter propensity score matching study. International Journal of Cancer 142(3): 641-648, 2018

Final trial report of sentinel-node biopsy versus nodal observation in melanoma. New England Journal of Medicine 370(7): 599-609, 2014

Comparison between F-Fluorodeoxyglucose Positron Emission Tomography and Sentinel Lymph Node Biopsy for Regional Lymph Nodal Staging in Patients with Melanoma: A Review of the Literature. Radiology Research and Practice 2011: 912504, 2011

Sentinel lymph node biopsy in patients with thin melanoma: occurrence of nodal metastases and its prognostic value. European Journal of Dermatology 20(1): 30-34, 2010

Sentinel lymph node biopsy for early cervical cancer: Results of a randomized prospective, multicenter study (Senticol 2) comparing adding pelvic lymph node dissection vs sentinel node biopsy only. Gynecologic Oncology 145: 2-3, 2017

Regional nodal basin control is not compromised by previous sentinel lymph node biopsy in patients with melanoma. Annals of Surgical Oncology 7(3): 226-231, 2000

Sentinel Lymph Node Biopsy: Past and Present Implications for the Management of Cutaneous Melanoma with Nodal Metastasis. American Journal of Clinical Dermatology 19(Suppl 1): 24-30, 2018

Nodal failure after lymphatic mapping and negative sentinel lymph node biopsy in stage I or II melanoma patients. Melanoma Research 7(Suppl. 1): S29-S30, 1997