+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sepsis is characterized by the increases in percentages of circulating CD4+CD25+ regulatory T cells and plasma levels of soluble CD25



Sepsis is characterized by the increases in percentages of circulating CD4+CD25+ regulatory T cells and plasma levels of soluble CD25



Tohoku Journal of Experimental Medicine 216(1): 61-68



The function of immune system is to protect hosts from invading microorganisms by destroying infected cells while minimizing damage to tissues. Among immune cells, CD4(+)CD25(+) regulatory T cells (Treg cells) control immune responses by limiting infectious processes. However, it remains unclear whether Treg cells are induced in systemic inflammatory response syndrome (SIRS) or infectious SIRS (i.e. sepsis). SIRS and sepsis are associated with stressful inflammatory conditions. We therefore measured CD25(+) T cells and circulating CD4(+) T cells, along with plasma levels of CD25, interleukin (IL)-6, and IL-10, in 20 septic patients (64 +/- 11 years), 16 SIRS patients (59 +/- 16 years), and control subjects: 13 elderly (60 +/- 16 years) and 14 young volunteers (28 +/- 3 years). Septic patients (23.3 +/- 11.8%, p < 0.01) showed significantly higher percentages of CD25(+) cells among CD4(+) T cells (i.e. Treg cells) than did either young (10.6 +/- 3.7%) or elderly volunteers (11.1 +/- 3.8%). The percentages of Treg cells in septic patients were higher than those in SIRS patients (12.4 +/- 6.9%, p < 0.01). Moreover, plasma levels of soluble CD25 were significantly higher in septic patients, compared to the levels in SIRS patients or volunteers (p < 0.01). No significant difference in plasma levels of IL-6 or IL-10 was found between septic patients and SIRS patients. Thus, sepsis is associated with the increased percentages of Treg cells and elevated plasma level of soluble CD25. The elevation of these parameters might be a useful marker of infections in SIRS.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055717674

Download citation: RISBibTeXText

PMID: 18719339

DOI: 10.1620/tjem.216.61


Related references

Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cells. Journal of Immunology 178(7): 4051-4061, 2007

CD25-positive cells during pregnancy: Differential profile of cytokines and soluble MHC antigens produced by CD25+CD4+ and CD25+CD8+ cells. Journal of Reproductive Immunology 71(2): 173-0, 2006

T cell receptor beta chain (TCR-Vbeta) repertoire of circulating CD4(+) CD25(-), CD4(+) CD25(low) and CD4(+) CD25(high) T cells in patients with long-term renal allograft survival. Transplant International 23(1): 54-63, 2010

CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Foundation Symposium 252: 67-88; Discussion 88-91, 106-14, 2003

Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Critical Care Medicine 31(7): 2068-2071, 2003

Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells. Journal of Immunology 173(1): 267-274, 2004

Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. Journal of Immunology 174(11): 7141-7146, 2005

Decreased levels of circulating CD4+CD25+Foxp3+ regulatory T cells in patients with primary antiphospholipid syndrome. Journal of Clinical Immunology 33(4): 876-879, 2013

Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25 high FOXP3 + Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy. Frontiers in Immunology 8: 1782, 2018

Circulating CD4+CD25+ and CD4+CD25+ T cells in myasthenia gravis and in relation to thymectomy. Scandinavian Journal of Immunology 59(4): 408-414, 2004

Defective functions of circulating CD4+CD25+ and CD4+CD25- T cells in patients with chronic ordinary urticaria. Journal of Dermatological Science 51(2): 121-130, 2008

Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccine. Breast Cancer Research and Treatment 98(1): 17-29, 2006

Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors. Allergy 64(8): 1121-1129, 2009

Regulatory CD25+CD4+ and CD25+CD8+ T cells display stimulatory activity during syngeneic pregnancy. Journal of Reproductive Immunology 81(2): 144-0, 2009

Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance. Journal of Immunology 168(11): 5558-5565, 2002