+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Serum glucocorticoids and adiponectin associate with insulin resistance in children born small for gestational age



Serum glucocorticoids and adiponectin associate with insulin resistance in children born small for gestational age



European Journal of Endocrinology 162(3): 551-557



Altered glucocorticoid activity is one possible mechanism linking fetal growth restriction with later insulin resistance (IR) and type 2 diabetes. We aimed to investigate whether serum glucocorticoid parameters are related to IR in children born small for gestational age (SGA). A total of 110 children (55 age- and gender-matched pairs born SGA or appropriate for gestational age (AGA) in a case-control setting) were studied at the mean age of 12.2 (s.d. 0.2) years. Serum cortisol, corticosteroid-binding globulin (CBG), free cortisol index (FCI=cortisol/CBG), and glucocorticoid bioactivity (GBA, transactivation assay) were analyzed and related to serum adiponectin and insulin-like growth factor-binding protein 1 (IGFBP1) concentrations and homeostasis model assessment for IR (HOMA-IR) and QUICKI indices. In the pooled study population, GBA correlated well with cortisol and FCI (r=0.681 and 0.586 respectively; P<0.001 for both). Serum cortisol, CBG, FCI, GBA, HOMA-IR, or QUICKI did not differ between the SGA and AGA subjects, but the SGA children had lower body mass index (P=0.005) and waist circumference (WC) (P=0.001). The mean GBA in the highest GBA quartile was higher among the SGA subjects than among the AGA subjects (138.6 vs 96.4 nmol/l cortisol equivalents, P<0.001). In the SGA children, GBA correlated positively with HOMA-IR (r=0.522, P<0.001) and inversely with adiponectin (r=-0.278, P=0.042) (WC/height ratio adjustments), and in logistic regression analysis, higher GBA (odds ratio (OR) 1.3; P=0.013), lower adiponectin (OR 1.4; P=0.038), and lower IGFBP1 (OR 1.9; P=0.010) associated independently with higher HOMA-IR. These findings suggest that increased glucocorticoid activity and low serum adiponectin concentrations associate with IR in SGA children.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055731092

Download citation: RISBibTeXText

PMID: 20019129

DOI: 10.1530/EJE-09-1003


Related references

Serum adiponectin levels, insulin resistance, and lipid profile in children born small for gestational age are affected by the severity of growth retardation at birth. European Journal of Endocrinology 156(2): 271-277, 2007

Serum levels of adiponectin and leptin in children born small for gestational age: relation to insulin sensitivity parameters. Journal of Pediatric Endocrinology & Metabolism 23(5): 463-471, 2010

Low serum adiponectin levels are associated with reduced insulin sensitivity and lipid disturbances in short children born small for gestational age. Clinical Endocrinology 83(1): 78-84, 2016

Serum adiponectin and leptin levels and insulin resistance in children born large for gestational age are affected by the degree of overweight. Clinical Endocrinology 66(3): 353-359, 2007

Differences in insulin resistance markers between children born small for gestational age or born preterm appropriate for gestational age. Acta Paediatrica 101(12): 1217-1224, 2013

Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity. International Journal of Obesity 30(1): 83-87, 2006

Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age. Clinical Endocrinology 66(2): 290-294, 2007

Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age. Nutrition & Metabolism 9(1): 107-107, 2012

Association of serum lipid concentrations, insulin resistance index and catch-up growth with serum cortisol/cortisone ratio by liquid chromatography tandem mass spectrometry in children born small for gestational age. Pediatric Research 58(3): 467-471, 2005

Insulin, adiponectin, IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages. Clinical Endocrinology 69(1): 88-92, 2007

Adiponectin is an indicator of insulin resistance in non-obese prepubertal children born large for gestational age (LGA) and is affected by birth weight. Clinical Endocrinology 70(5): 710-716, 2008

Insulin resistance and oxidative stress in children born small and large for gestational age. Pediatrics 124(2): 695-702, 2009

Serum markers of GH and insulin action in 12-year-old children born small for gestational age. European Journal of Endocrinology 152(3): 335-340, 2005

The somatotropic axis in short children born small for gestational age: relation to insulin resistance. Pediatric Research 51(1): 76-80, 2002

Insulin resistance and its association with catch-up growth in Chinese children born small for gestational age. Obesity 25(1): 172-177, 2016