+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Seven-year experience of enterocutaneous fistula with univariate and multivariate analysis of factors associated with healing: development of a validated scoring system



Seven-year experience of enterocutaneous fistula with univariate and multivariate analysis of factors associated with healing: development of a validated scoring system



Colorectal Disease 15(9): 1162-1170



The management of enterocutaneous fistulae (ECF) is complex and challenging. We examined factors associated with fistula healing at a National Intestinal Failure Centre and devised the first scoring system to predict spontaneous fistula healing prior to surgery. A retrospective audit of 177 patients (mean age 48.7 years) treated over 7 years was undertaken. Results were compared with a previously reported series from this unit. Univariate and multivariate analyses wete performed on variables to assess relationship with ECF healing. A scoring system was devised and validated on a prospective cohort. One-hundred and fifty patients underwent surgery between January 2003 and December 2009. The overall healing rate following surgery in the current series was 94.6% (82% in the previous series). Mean delay from previous surgery to the current operation was 1 year (compared with 8 months previously). Thirty-day postfistula resection mortality was 0% (compared with 3.5% previously). Twenty-seven patients underwent medical management alone with overall healing rate of 46.4% (vs 19.9%). Multivariate analysis revealed that comorbidity (P = 0.02), source of referral (P = 0.01) and aetiology (P = 0.006) had associations with healing. Almost all patients with scores of 0 and 1 healed, whereas the highest scores healed least frequently. Surgical management of ECF is safe and improving. Fistula healing is affected by aetiology, comorbidity and source of referral. The scoring system has the potential to predict ECF healing and can be a useful clinical decision-making tool.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055736892

Download citation: RISBibTeXText

PMID: 23869525

DOI: 10.1111/codi.12363


Related references

Seven year experience of enterocutaneous fistula with univariate and multivariate analysis of factors associated with healingdevelopment of a validated scoring system. Colorectal Disease, 2013

A 16-year experience with 1275 primary living donor kidney transplants: univariate and multivariate analysis of risk factors affecting graft survival. Transplantation Proceedings 28(3): 1578-1579, 1996

Multivariate and univariate analysis of prognostic factors following resection in HCC: the Birmingham experience. Digestive Surgery 23(1-2): 103-109, 2006

Univariate and multivariate analysis of risk factors for graft failure after liver transplants A single-center experience. Hepatology. 24(4 Part 2): 504a, 1996

An 11-year experience of enterocutaneous fistula. British Journal of Surgery 91(12): 1646-1651, 2004

Clinical and Histological Prognostic Factors in Axillary Node-Negative BreastCancer: Univariate and Multivariate Analysis with Relation to 5-Year Recurrence. Breast Cancer 2(1): 51-58, 1995

Risk factors for the development of postoperative complications after bronchial sleeve resection for malignancy: a univariate and multivariate analysis. Annals of Thoracic Surgery 75(3): 966-972, 2003

Single center experience of 1000 primary living donor kidney transplants: univariate and multivariate analysis of risk factors affecting graft survival. Transplantation Proceedings 26(4): 2159-2160, 1994

Definitive surgical treatment of enterocutaneous fistula: outcomes of a 23-year experience. JAMA Surgery 148(2): 118-126, 2013

Surgery for high-output small bowel enterocutaneous fistula: a 30-year experience. International Surgery 94(3): 262-268, 2010

Prognostic factors in gestational trophoblastic tumors a proposed new scoring system based on multivariate analysis. American Journal of Obstetrics & Gynecology 164(2): 611-616, 1991

Factors linked to 5-year survival after hepatectomy for hepatocellular carcinoma: univariate and multivariate analyses of 312 patients. Fukuoka Igaku Zasshi 90(7): 324-328, 1999

Validated univariate and multivariate spectrophotometric methods for the determination of pharmaceuticals mixture in complex wastewater. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 140: 451-461, 2015

Risk factors in non hodgkin lymphomas univariate vs multivariate analysis. 1986