+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Severe hyponatraemia to terlipressin treatment

Severe hyponatraemia to terlipressin treatment

Ugeskrift for Laeger 175(39): 2250-2251

Terlipressin is a vasopressin analogue. The clinical effect is attributable to affinity to vasopressin-1a receptors. However, it also has affinity to renal vasopressin-2 receptors, which can lead to water retention and dilutional hyponatraemia. We report a case of severe hyponatraemia secondary to terlipressin treatment. A 60-year-old woman with bleeding oesophageal varices was treated with terlipressin 2 mg every fourth hour. After 24 hours of treatment she was somnolent, and the sodium concentration had dropped from 127 mmol/l to 107 mmol/l. Hyponatraemia is an important adverse event in terlipressin treatment, and serum sodium should be monitored closely.

(PDF emailed within 1 workday: $29.90)

Accession: 055739642

Download citation: RISBibTeXText

PMID: 24063710

Related references

Terlipressin and hyponatraemia: the cause or the treatment?. Internal Medicine Journal 43(5): 606-607, 2014

Hyponatraemia during terlipressin therapy. Gut 59(3): 417-418, 2010

Hyponatraemia induced by terlipressin: a case report and literature review. Journal of Clinical Pharmacy and Therapeutics 40(6): 626-628, 2016

Prognosis of patients with severe hyponatraemia is related not only to hyponatraemia but also to comorbidities and to medical management: results of an observational retrospective study. Bmc Nephrology 17(1): 159, 2016

Severe hyponatraemia: complications and treatment. Qjm 88(12): 905-909, 1995

The treatment of severe hemoptysis by terlipressin a study of the efficacy and acceptability of the product. Revue des Maladies Respiratoires 6(4): 365-368, 1989

Severe reversible penile ischaemia after terlipressin treatment of hepatorenal syndrome. Ugeskrift for Laeger 180(43), 2018

Severe hyponatraemia: current concepts on pathogenesis and treatment. National Medical Journal of India 14(5): 277-283, 2002

Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome. Clinical and Molecular Hepatology 19(4): 417-420, 2014

Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: a multicenter, double-blind study. New Italian Endoscopic Club. Hepatology 18(5): 1102-1107, 1993

Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrology, Dialysis, Transplantation 21(1): 70-76, 2005

Osmotic myelinolysis syndrome after treatment of severe deamino arginine vasopressin-associated hyponatraemia: pitfalls in emergency medicine. Emergency Medicine Australasia 19(1): 68-70, 2007

Real-life experience of tolvaptan use in the treatment of severe hyponatraemia due to syndrome of inappropriate antidiuretic hormone secretion. Clinical Endocrinology 84(4): 620-626, 2016

Severe hyponatraemia and severe hyperkalaemia in an HIV positive patient who received high dose co-trimoxazole. Sexually Transmitted Infections 74(1): 75-76, 1998

Severe hyponatraemia during invasive pulmonary aspergillosis treatment with voriconazole in a octogenarian patient with chronic obstructive pulmonary disease. Revista Espanola de Geriatria Y Gerontologia 48(5): 249-250, 2014