+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Severe hypospadias and its association with maternal-placental factors



Severe hypospadias and its association with maternal-placental factors



American Journal of Medical Genetics. Part a 161a(9): 2183-2187



The neonate born small for gestational age (SGA, birth weight <10th centile) with severe hypospadias, and without the presence of other malformations, is a presentation which clinical geneticists are asked to assess. However, this combination is not well addressed in the literature. Epidemiological studies point to an increased incidence and severity of hypospadias in SGA infants, but leave open the possibility that the association is attributable to the population subset who have multiple congenital abnormalities or genetic syndromes. Epidemiological studies unselected for birth weight have also identified an association between hypospadias with some risk factors tied to SGA, including prematurity, preeclampsia, and placental insufficiency. This study was developed after being involved in the care of several boys with SGA and severe hypospadias who were premature, with gestational histories of maternal hypertension and oligohydramnios. No underlying syndromes, hormonal abnormalities, or contributory family histories could be found. We hypothesized that severe hypospadias may in some cases be causally related to maternal-placental factors rather than primary fetal abnormalities. A retrospective study of a cohort of singletons born SGA with unexplained hypospadias was conducted. We compared their gestational histories and hypospadias severities with those born at normal birth weights. The cohort with SGA had an increased ratio of severe to mild hypospadias. Further, within the cohort of SGA boys, there was a higher prevalence of prematurity, maternal hypertension, and oligohydramnios among those with severe vs mild hypospadias. Small sample sizes are limiting.

(PDF emailed within 0-6 h: $19.90)

Accession: 055739686

Download citation: RISBibTeXText

PMID: 23913586

DOI: 10.1002/ajmg.a.36050


Related references

Maternal and fetal risk factors associated with severity of hypospadias: a comparison of mild and severe cases. Journal of Pediatric Urology 5(4): 283-286, 2009

Lack of association between placental thrombosis and maternal thrombophilia in severe preterm IUGR. American Journal of Obstetrics & Gynecology 185(6 Supplement): S258, December, 2001

Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma: placental findings. Annals of the Rheumatic Diseases 69(2): 458-461, 2010

Maternal uniparental disomy for chromosome 2 in association with confined placental mosaicism for trisomy 2 and severe intrauterine growth retardation. Prenatal Diagnosis 16(10): 958-962, 1996

Genetic, maternal and placental factors in the association between birth weight and physical fitness: a longitudinal twin study. Plos One 8(10): E76423, 2015

Placental genome and maternal-placental genetic interactions: a genome-wide and candidate gene association study of placental abruption. Plos One 9(12): E116346, 2015

The mode of insertion of umbilical cord and vessels: Association with maternal haemoglobin genotype, neonatal factors,. and placental component volumes. Anatomy and Embryology 189(2): 107-114, 1994

Placental pathology in patients with elevated msafp association with placental sonolucencies and feto maternal hemorrhage. American Journal of Obstetrics & Gynecology 164(1 PART 2): 289, 1991

Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. Journal of Clinical Endocrinology and Metabolism 99(4): 1348-1356, 2014

Maternal hypertension, antihypertensive medication use, and the risk of severe hypospadias. Birth Defects Research. Part A, Clinical and Molecular Teratology 82(1): 34-40, 2007

Maternal uniparental disomy of chromosome 2 and confined placental mosaicism for trisomy 2 in a fetus with intrauterine growth restriction, hypospadias, and oligohydramnios. Prenatal Diagnosis 17(5): 443-450, 1997

Relationship of maternal placental blood flow to the placental clearance of maternal plasma dehydroisoandrosterone sulfate through placental estradiol formation. American Journal of Obstetrics and Gynecology 136(4): 435-439, 1980

Placental growth factor in the first trimester: relationship with maternal factors and placental Doppler studies. Ultrasound in Obstetrics and Gynecology 35(3): 280-285, 2010

Maternal and gestational risk factors for hypospadias. Environmental Health Perspectives 116(8): 1071-1076, 2008