+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency



Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency



European Journal of Pediatrics 173(12): 1591-1594



Bordetella pertussis or whooping cough is a vaccine-preventable disease that still remains a serious infection in neonates and young infants. We describe two young infants, monozygotic twins, with a severe B. pertussis pneumonia of whom one needed extracorporeal membrane oxygenation. Diagnostic work-up of unexplained hematuria and proteinuria during the illness revealed low serum complement component 3 (C3) levels. During follow-up, C3 levels remained low (400-600 mg/L). Extensive analysis of the persistent low C3 levels revealed an unknown heterozygous mutation in the C3 gene in both siblings and their mother. This C3 mutation in combination with the specific virulence mechanisms of B. pertussis probably contributed to the severe disease course in these cases. We propose that genetically caused complement disorders should be considered when confronted with severe cases of B. pertussis infection.

(PDF emailed within 0-6 h: $19.90)

Accession: 055739786

Download citation: RISBibTeXText

PMID: 23963626

DOI: 10.1007/s00431-013-2107-3


Related references

Monozygotic Twins Concordant For Ventricular Septal Defects. Case Report And Review Of The Literature Of Congenital Heart Disease In Monozygotic Twins. American Journal of Cardiology 15: 386-390, 1965

Severe Bordetella pertussis pneumonia in an immunocompetent adult. Medecine et Maladies Infectieuses 42(2): 82-83, 2012

Juvenile idiopathic polyarthritis in monozygotic twins with congenital C4 deficiency. La Revue de Medecine Interne 25(8): 604-606, 2004

Severe congenital systemic juvenile xanthogranuloma in monozygotic twins. Pediatric Dermatology 25(4): 470-473, 2008

Bordetella pertussis infection in children with severe pneumonia, Philippines, 2012-2015. Vaccine 35(7): 993-996, 2017

Severe pneumonia and chronic lung disease in a young child with adenovirus and Bordetella pertussis infection. Pediatric Infectious Disease Journal 14(5): 400-401, 1995

Variable expressivity of congenital longitudinal radial deficiency and spinal dysraphism in monozygotic twins. Turkish Journal of Pediatrics 47(4): 390-392, 2005

Monozygotic twinning as a congenital defect and congenital defects in monozygotic twins. Fetal Diagnosis and Therapy 5(2): 61-69, 1990

Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. Infection and Immunity 67(3): 1050-1055, 1999

Elizabeth M. Bryan: tributes from home and abroad; research reviews: anorexia nervosa in opposite-sex twins, twin study of self-esteem, DNA differences in monozygotic twins; twins and more twins: twins living apart, twins playing together, twins working together, twins playing apart, multiple birth odds. Twin Research and Human Genetics 11(3): 357-361, 2008

Infantile masturbation in monozygotic twins. Journal of Sexual Medicine 9(1): 331-332, 2012

Infantile autism in monozygotic twins. Journal of the American Academy of Child Psychiatry 24(5): 643-646, 1985

Infantile spasms syndrome in monozygotic twins. Archives of Disease in Childhood 55(11): 870-872, 1980

Infantile spasm in 2 monozygotic twins. A new case. Presse Medicale 15(10): 485, 1986

Early infantile autism in monozygotic twins. Journal of Autism and Developmental Disorders 9(1): 105-109, 1979