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Severe infections in a cohort of patients with systemic lupus erythematosus



Severe infections in a cohort of patients with systemic lupus erythematosus



Medicina Clinica 135(8): 365-367



To study severe infectious complications in a cohort of patients with systemic lupus erythematosus (SLE). Retrospective study of 705 patients followed from January 1980 to January 2008. Data are expressed in percentages. The frequency of severe infectious was 38.6%. The etiology was bacterial 54.4%, viric 30.4% and opportunist in 15.2% patients. Involved organs were: Lung 38.2%, kidney 48.9%, central nervous system 43%. 43.75% patients received pulsed ciclofosfamide therapy and 88.6% received glucocorticoids (39.7% pulsed). The mortality was 27.7%. At present, infection is an important cause of mortality in patients with SLE. Early diagnosis of infectious complications is very important in SLE.

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Accession: 055739807

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PMID: 20541779

DOI: 10.1016/j.medcli.2010.03.026


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