+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence



Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence



Infectious Disease Clinics of North America 27(3): 631-649



Pathogenic Escherichia coli are genetically diverse and encompass a broad variety of pathotypes, such as enteroaggregative E. coli (EAEC) or enterohemorrhagic E. coli (EHEC), which cause distinct clinical syndromes. The historically large 2011 German outbreak of hemolytic uremic syndrome (HUS), caused by a Shiga-toxin producing E. coli (STEC) of the serotype O104:H4, illustrated the emerging importance of non-O157 STEC. STEC O104:H4, with features characteristic of both enteroaggregative E. coli and enterohemorrhagic E. coli, represents a unique and highly virulent pathotype. The German outbreak both allowed for the evaluation of several potential therapeutic approaches to STEC-induced HUS and emphasizes the importance of early and specific detection of both O157 and non-O157 STEC.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055755813

Download citation: RISBibTeXText

PMID: 24011834

DOI: 10.1016/j.idc.2013.05.002


Related references

Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. Mbio 4(1): E00452-12, 2013

Escherichia coli O104:H4 Pathogenesis: an Enteroaggregative E. coli/Shiga Toxin-Producing E. coli Explosive Cocktail of High Virulence. Microbiology Spectrum 2(6): -, 2016

Genotypes and virulence characteristics of Shiga toxin-producing Escherichia coli O104 strains from different origins and sources. International Journal of Medical Microbiology 303(8): 410-421, 2014

Approaches to treatment of emerging Shiga toxin-producing Escherichia coli infections highlighting the O104:H4 serotype. Frontiers in Cellular and Infection Microbiology 5: 24-24, 2015

Comparative virulence characterization of the Shiga toxin phage-cured Escherichia coli O104:H4 and enteroaggregative Escherichia coli. International Journal of Medical Microbiology, 2018

Shiga toxin-producing Escherichia coli O104H4 An emerging important pathogen in food safety. Chinese Science Bulletin 58(14): 1625-1631, 2013

Shiga toxin-producing Escherichia coli O104:H4: a new challenge for microbiology. Applied and Environmental Microbiology 78(12): 4065-4073, 2012

Emerging Public Health Challenges of Shiga Toxin-Producing Escherichia coli Related to Changes in the Pathogen, the Population, and the Environment. Clinical Infectious Diseases 64(3): 371-376, 2016

Shiga toxin-producing Escherichia coli and their bacteriophages as a model for the analysis of virulence and stress response of a food-borne pathogen. Berliner und Munchener Tierarztliche Wochenschrift 120(7-8): 288-295, 2007

Enteroaggregative Shiga toxin-producing Escherichia coli of serotype O104:H4 in Belgium and Luxembourg. New Microbes and New Infections 2(5): 138-143, 2014

Blinded by shiga toxin-producing O104 Escherichia coli and hemolytic uremic syndrome. Journal of Pediatrics 165(2): 410-410.E1, 2014

A new health threat in Europe: Shiga toxin-producing Escherichia coli O104:H4 infections. Journal of Microbiology, Immunology, and Infection 44(5): 390-393, 2012

Similarity of Shiga toxin-producing Escherichia coli O104:H4 strains from Italy and Germany. Emerging Infectious Diseases 17(10): 1957-1958, 2012

Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. New England Journal of Medicine 365(19): 1771-1780, 2011

Detection and isolation of Shiga toxin-producing Escherichia coli (STEC) O104 from sprouts. International Journal of Food Microbiology 173: 99-104, 2014