+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Shigella hacks host immune responses by reprogramming the host epigenome



Shigella hacks host immune responses by reprogramming the host epigenome



Embo Journal 33(22): 2598-2600



Bacterial pathogens alter host transcriptional programs to promote infection. Shigella OspF is an essential virulence protein with a unique phosphothreonine lyase activity. A new study in The EMBO Journal (Harouz et al, 2014) reveals a novel function of OspF: targeting of heterochromatin protein 1γ (HP1γ) and downregulation of a subset of immune genes. These results illustrate how bacterial pathogens exploit epigenetic modifications to counteract host immune responses.

(PDF emailed within 0-6 h: $19.90)

Accession: 055755876

Download citation: RISBibTeXText

PMID: 25246515

DOI: 10.15252/embj.201489934


Related references

Shigella deploy multiple countermeasures against host innate immune responses. Current Opinion in Microbiology 14(1): 16-23, 2011

Shigella manipulates host immune responses by delivering effector proteins with specific roles. Frontiers in Immunology 6: 219-219, 2015

Delayed hypersensitivity in relation to host cellular immune responses in Shigella infected mice. Immunology & Infectious Diseases (Oxford) 4(3): 149-154, 1994

Differential host immune responses to epidemic and endemic strains of Shigella dysenteriae type I. Journal of Health, Population, and Nutrition 29(5): 429-437, 2011

Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochemical and Biophysical Research Communications 333(2): 531-539, 2005

Host immune potentiation of drug responses to a murine mammary adenocarcinoma. II. Effect of melphalan therapy on the host immune system. International Journal of Cancer 18(5): 630-638, 1976

Host immune potentiation of drug responses to a murine mammary adeno carcinoma part 2 effect of melphalan therapy on the host immune system. International Journal of Cancer 18(5): 630-638, 1976

Tumor cell diversity and host responses in cancer metastasis--part II--host immune responses and therapy of metastases. Current Problems in Cancer 7(7): 1-42, 1983

Lactobacilli inhibit Shigella dysenteriae 1 induced pro-inflammatory response and cytotoxicity in host cells via impediment of Shigella-host interactions. Digestive and Liver Disease 42(1): 33-39, 2010

Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones. Cellular Microbiology 17(8): 1098-1107, 2016

Temporal progression of host lymphocyte immune responses to EL4 growing in its syngeneic host. Proceedings of the American Association for Cancer Research Annual Meeting 40: 182, March, 1999

Requirement for host Fc receptors and IgG antibodies in host immune responses against Rhipicephalus appendiculatus. Veterinary Parasitology 28(1-2): 153-161, 1988

Host immune responses during progressive growth in its syngeneic host of EL4. Proceedings of the American Association for Cancer Research Annual Meeting 39: 533, March, 1998

Inhibition of induction and expression of host-protective immune responses in infected host: parasite-protective (proparasitic) responses and immunosuppression. African Journal of Clinical and Experimental Immunology 2(4): 295-303, 1981

Experimental host-parasite relationship studies with Oesophagostomum columbianum in sheep. II. Some effects of subcutaneous infections upon host immune and hypersensitive responses. Research in Veterinary Science 9(4): 358-365, 1968