+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold



Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold



Journal of Cardiovascular Magnetic Resonance 12: 69



T1 mapping allows direct in-vivo quantitation of microscopic changes in the myocardium, providing new diagnostic insights into cardiac disease. Existing methods require long breath holds that are demanding for many cardiac patients. In this work we propose and validate a novel, clinically applicable, pulse sequence for myocardial T1-mapping that is compatible with typical limits for end-expiration breath-holding in patients. The Shortened MOdified Look-Locker Inversion recovery (ShMOLLI) method uses sequential inversion recovery measurements within a single short breath-hold. Full recovery of the longitudinal magnetisation between sequential inversion pulses is not achieved, but conditional interpretation of samples for reconstruction of T1-maps is used to yield accurate measurements, and this algorithm is implemented directly on the scanner. We performed computer simulations for 100 ms

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055762174

Download citation: RISBibTeXText

PMID: 21092095

DOI: 10.1186/1532-429x-12-69


Related references

A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look-Locker inversion recovery T 1 (shMOLLI-T 1 ) in the liver. Journal of Magnetic Resonance Imaging 45(2): 450-462, 2017

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI). Magnetic Resonance in Medicine 78(5): 1746-1756, 2017

Inversion group (IG) fitting: A new T1 mapping method for modified look-locker inversion recovery (MOLLI) that allows arbitrary inversion groupings and rest periods (including no rest period). Magnetic Resonance in Medicine 75(6): 2332-2340, 2016

Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magnetic Resonance in Medicine 52(1): 141-146, 2004

Improved segmented modified Look-Locker inversion recovery T1 mapping sequence in mice. Plos one 12(11): E0187621, 2017

Selection of magnetization catalyzation and readout methods for modified Look-Locker inversion recovery: a T1 mapping primer. Magnetic Resonance Imaging 33(4): 363-373, 2015

Modified look-locker inversion recovery T1 mapping indices: assessment of accuracy and reproducibility between magnetic resonance scanners. Journal of Cardiovascular Magnetic Resonance 15: 64, 2013

Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping. Circulation. Cardiovascular Imaging 4(6): 636-640, 2011

Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart. Journal of Magnetic Resonance Imaging 26(4): 1081-1086, 2007

Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients. Journal of Computer Assisted Tomography 42(5): 732-738, 2018

Quantitative assessment of hepatic function: modified look-locker inversion recovery (MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging. European Radiology 26(6): 1775-1782, 2016

Fast myocardial T 1 mapping using shortened inversion recovery based schemes. Journal of Magnetic Resonance Imaging 50(2): 641-654, 2019

Consideration of slice profiles in inversion recovery Look-Locker relaxation parameter mapping. Magnetic Resonance Imaging 32(8): 1021-1030, 2014

Influence of fat on liver T1 measurements using modified Look-Locker inversion recovery (MOLLI) methods at 3T. Journal of Magnetic Resonance Imaging 44(1): 105-111, 2016

BLOCH equations-based reconstruction of myocardium t1 maps from modified look-locker inversion recovery sequence. Plos one 10(5): E0126766, 2015