+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Simulated evolution of the vertebral body based on basic multicellular unit activities



Simulated evolution of the vertebral body based on basic multicellular unit activities



Journal of Bone and Mineral Metabolism 29(4): 466-476



A numerical model based on the theory of bone remodeling is proposed to predict the evolution of trabecular bone architecture within the vertebral body and to investigate the process of degeneration in vertebral bone. In this study, particular attention is paid on the description of microstructure changes during the aging process. To take into account the effect of basic multicellular units (BMUs), a set of computational algorithms has been developed. It is assumed that BMU activation probability depends on the state of damaged bone tissue (damage accumulation, ω), which is evaluated according to previous research concerning bone fatigue damage. Combining these algorithms with the finite-element method (FEM), the microstructure of vertebral bone has been predicted for up to 8 simulated years. Moreover, biomechanical material properties have been monitored to investigate the changes of vertebral bone with age. This study shows that the simulation based on BMU activities has the potential to define and predict the morphological evolution of the vertebral body. It can be concluded that the novel algorithms incorporating the coupled effects of both adaptive remodeling and microdamage remodeling could be utilized to gain greater insight into the mechanism of bone loss in the elderly population.

(PDF emailed within 0-6 h: $19.90)

Accession: 055783168

Download citation: RISBibTeXText

PMID: 21188609

DOI: 10.1007/s00774-010-0244-6


Related references

Some effects of basic multicellular unit-based remodelling on photon absorptiometry of trabecular bone. Bone and Mineral 7(1): 47-65, 1989

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model. Bone 50(1): 378-389, 2012

Female Human Spines with Simulated Osteolytic Defects: CT-based Structural Analysis of Vertebral Body Strength. Radiology: 171139-171139, 2018

Biology of the basic multicellular unit and the pathophysiology of osteoporosis. Medical and Pediatric Oncology 41(3): 182-185, 2003

A theoretical analysis of the changes in basic multicellular unit activity at menopause. Bone (New York) 32(4): 357-363, April, 2003

Lacunocanalicular fluid flow and regulation of Basic Multicellular Unit activity.. 2007

The relationship between basic multicellular unit activation and origination in cancellous bone. Bone (New York) 25(5): 585-587, 1999

Effects of the basic multicellular unit and lamellar thickness on osteonal fatigue life. Journal of Biomechanics 60: 116-123, 2017

Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression. Bone 30(1): 5-7, 2002

Dynamics of bone remodeling explained by Harold Frost. Theory of the B. M.U. (basic multicellular unit). La Nouvelle Presse Medicale 4(6): 421-424, 1975

Modelling geometrically accurate basic-multicellular-unit morphologies: Implications for regulation of cortical bone remodelling. Journal of Biomechanics 39: S410-S411, 2006

Three-dimensional microcomputed tomography imaging of basic multicellular unit-related resorption spaces in human cortical bone. Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology 288(7): 806-816, 2006

Morphological assessment of basic multicellular unit resorption parameters in dogs shows additional mechanisms of bisphosphonate effects on bone. Calcified Tissue International 86(1): 67-71, 2010

Association of early physical activity time with pain, activities of daily living, and progression of vertebral body collapse in patients with vertebral compression fractures. European Journal of Physical and Rehabilitation Medicine 53(3): 366-376, 2016

Cell-cell signaling: broadening our view of the basic multicellular unit. Calcified Tissue International 94(1): 2-3, 2014