+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Simulated visual fields produced from macular RNFLT data in patients with glaucoma



Simulated visual fields produced from macular RNFLT data in patients with glaucoma



Current Eye Research 38(11): 1133-1141



We investigated in detail the correlation between structure and function in the macula, and whether optical coherence tomography (OCT)-measured macular structure could be used to simulate the visual field. This study comprised 60 eyes of 34 patients with open angle glaucoma (Anderson-Patella classification). To assess macular function, reliable data from the Humphrey field analyzer (HFA, SITA-standard, 10-2 program) for threshold, total deviation (TD), and pattern deviation (PD) were used. To assess macular structure, thickness data for the retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and ganglion cell layer plus inner plexiform layer (GCL + IPL) from macular OCT maps (3D OCT-2000, Topcon) were analyzed. Spearman's coefficient of correlation analysis was performed to determine the significance of the correlation, as well as the formula for simulation. The formula was used to calculate the simulated threshold, TD, and PD values. The simulation method was validated by comparing results for simulated and actual visual fields in a new data set of 29 eyes from glaucoma patients. In most test points, macular function and the layer-by-layer structure were significantly correlated, however, the distribution of highly-correlated points varied. Simulated grayscale maps of the visual field based on the formula of regression line for RNFLT and thresholds were similar to actual visual fields. There was a significant correlation between simulated visual fields created from RNFLT, GCC and GCL + IPL data and actual average threshold values in all 68 test points (r = 0.63-0.87, p < 0.001) and TD (r = 0.62-0.86, p < 0.001). We found that there was a significant correlation between structure and function in the macular area, and that simulated visual fields from RNFLT data reflected actual visual fields. Such a simulation of macular function from OCT parameters may be useful in assessing glaucoma in patients who have difficulty undergoing actual visual field examinations.

(PDF emailed within 0-6 h: $19.90)

Accession: 055783372

Download citation: RISBibTeXText

PMID: 23844647

DOI: 10.3109/02713683.2013.807932


Related references

Macular Thickness Assessment in Patients with Glaucoma and Its Correlation with Visual Fields. Journal of Current Glaucoma Practice 10(3): 85-90, 2016

Correlation of macular thickness with visual fields in glaucoma patients and suspects. Journal of Glaucoma 23(2): E98-104, 2014

Effect of simulated altitude on the visual fields of glaucoma patients and the elderly. Optometry and Vision Science 68(5): 344-350, 1991

New method for recording of visual fields in patients with glaucoma. Use of electronic data processing. Polski Tygodnik Lekarski 33(24): 977-979, 1978

Testing for glaucoma with the frequency-doubling illusion in the whole, macular and eccentric visual fields. Australian and New Zealand Journal of Ophthalmology 27(3-4): 194-196, 1999

Glaucoma testing with the frequency doubled illusion presented to the whole, macular and eccentric visual fields. Investigative Ophthalmology & Visual Science 35(4): 2187, 1994

Variation of visual fields in glaucoma patients with split fixation fields. Investigative Ophthalmology & Visual Science 28(3 SUPPL): 269, 1987

Effect of systolic blood pressure on the location of visual field defects in upper and lower visual half-fields in patients with chronic simple glaucoma. Der Ophthalmologe 90(6): 620-625, 1993

Agreement of observers for assessment of Humphrey visual fields , PROGRESSOR pointwise linear analysis and the Advanced Glaucoma Intervention Study scoring system in detecting progression of visual field loss in glaucoma. IOVS 40(4): S69, March 15, 1999

Investigation of central visual fields in patients with age-related macular changes. Optometry and Vision Science 67(3): 179-183, 1990

Regional correlation of macular areas and visual acuity in patients with open-angle glaucoma. Clinical & Experimental Ophthalmology 43(3): 279-282, 2015

Effect of betaxolol and timolol on visual fields in glaucoma patients. Klinische Monatsblatter für Augenheilkunde 198(5): 330-331, 1991

Effect of cataract extraction on the visual fields of patients with glaucoma. Archives of Ophthalmology 123(7): 929-932, 2005

Influence of betaxolol and timolol on the visual fields of patients with glaucoma. American Journal of Ophthalmology 112(6): 678-681, 1991

Changes in the visual fields in glaucoma: static and kinetic perimetry in 2,000 patients. Transactions of the American Ophthalmological Society 77: 622-642, 1979