EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Single centre experience of ivabradine in postural orthostatic tachycardia syndrome



Single centre experience of ivabradine in postural orthostatic tachycardia syndrome



Europace 13(3): 427-430



Postural orthostatic tachycardia syndrome (POTS) is associated with tachycardia on orthostasis. Patients frequently report palpitations, presyncope, and fatigue. Conventional therapy is effective in less than 60%. Case reports suggest ivabradine (a selective sinus node blocker, with no effect on blood pressure) may alleviate POTS-related symptoms. This is a retrospective case-series. Postural orthostatic tachycardia syndrome patients prescribed ivabradine were identified from the pharmacy database. Case notes were reviewed and participants completed a symptom assessment tool. Twenty-two patients were identified. Data were available from 20. Eight patients reported reduced tachycardia and fatigue and four reported only reduced tachycardia. The most common reason for discontinuing ivabradine was lack of efficacy (n = 6). Five patients reported side-effects resulting in two discontinuing treatment. This retrospective case series indicates that 60% of patients treated with ivabradine report a symptomatic improvement. A randomized controlled trial accessing the efficacy of ivabradine in POTS is indicated, particularly in patients resistant to, or intolerant of, conventional therapy.

(PDF same-day service: $19.90)

Accession: 055793450

Download citation: RISBibTeXText

PMID: 21062792

DOI: 10.1093/europace/euq390



Related references

Ivabradine in Postural Orthostatic Tachycardia Syndrome: Preliminary Experience in Children. American Journal of Cardiovascular Drugs, 2017

Use of Ivabradine in Postural Orthostatic Tachycardia Syndrome. Journal of Atrial Fibrillation 3(2): 273-273, 2010

Treatment of inappropriate sinus tachycardia with ivabradine in a patient with postural orthostatic tachycardia syndrome and a dual chamber pacemaker. Pacing and Clinical Electrophysiology 32(1): 131-133, 2009

Ivabradine in the treatment of postural tachycardia syndrome (POTS), a single center experience. Pacing and Clinical Electrophysiology 40(11): 1242-1245, 2017

Ivabradine for the Treatment of Postural Orthostatic Tachycardia Syndrome: A Systematic Review. American Journal of Cardiovascular Drugs, 2018

Potentially new indication of ivabradine: treatment of a patient with postural orthostatic tachycardia syndrome. Open Cardiovascular Medicine Journal 4: 166-167, 2010

Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine. Europace 9(12): 1202-1202, 2007

Clinical presentation and management of patients with hyperadrenergic postural orthostatic tachycardia syndrome. A single center experience. Cardiology Journal 18(5): 527-531, 2012

Our experience in the diagnosis and treatment of postural orthostatic tachycardia syndrome, vasovagal syncope, and inappropriate sinus tachycardia in children. Turk Kardiyoloji Dernegi Arsivi 45(3): 227-234, 2017

Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience. Pacing and Clinical Electrophysiology 34(6): 750-755, 2012

Postural orthostatic tachycardia syndrome: the Mayo clinic experience. Mayo Clinic Proceedings 82(3): 308-313, 2007

BASCULE syndrome, orthostatic cyanosis and postural orthostatic tachycardia syndrome: time for decanting old wine?. British Journal of Dermatology 175(5): 1110-1111, 2016

Orthostatic intolerance: postural orthostatic tachycardia syndrome with overlapping vasovagal syncope. Acta Clinica Croatica 51(1): 93-95, 2012

Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. Journal of Applied Physiology 89(4): 1505-1512, 2000

Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome. European Journal of Neurology 11(9): 613-619, 2004