Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA
Ishizuka, T.; Komiyama, M.
Nucleic Acids Symposium Series 52: 141-142
2008
ISSN/ISBN: 1746-8272 PMID: 18776293 DOI: 10.1093/nass/nrn072
Accession: 055799978
We show that, in the presence of single-strand binding protein (SSB), one strand of peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in sequence-specific manner, as shown in Figure 1. In the absence of SSB, this kind of strand invasion never occurs. This significant enhancement of invasion can be applied to in vivo applications.
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