Home
  >  
Section 56
  >  
Chapter 55,818

Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells

Liu, Y.; Dong, Y.; Zhang, B.; Cheng, Y.-X.

Oncology Letters 6(2): 556-558

2013

ISSN/ISBN: 1792-1074
PMID: 24137368
DOI: 10.3892/ol.2013.1370
Accession: 055817367
Download citation:  
Text
  |  
BibTeX
  |  
RIS
6-O-angeloylplenolin (6-OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. In the present study, the levels of apoptosis were analyzed in dexamethasone-sensitive (MM.1S), dexamethasone-resistant (U266) and chemotherapy-sensitive (RPMI 8226) myeloma cell lines. Enhanced apoptosis was identified following a 48-h incubation with 6-OAP (0-10 μM) that induced a dose-dependent decrease in pro-casp-3 and the cleavage of its substrate, anti-poly (ADP-ribose) polymerase (PARP). In addition, time-dependent cleavage of PARP was also detected in U266 and MM.1S cells. The mechanism of 6-OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase-3 and PARP. In conclusion, 6-OAP-induced apoptosis is caspase-dependent. These observations are likely to provide a framework for future studies of 6-OAP therapy in MM.

PDF emailed within 0-6 h: $19.90




Related References

Liu, Y.; Chen, X.-Q.; Liang, H.-X.; Zhang, F.-X.; Zhang, B.; Jin, J.; Chen, Y.-L.; Cheng, Y.-X.; Zhou, G.-B. 2011: Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma Plos one 6(7): E21930
Yuan, X.-G.; Huang, Y.-R.; Yu, T.; Jiang, H.-W.; Xu, Y.; Zhao, X.-Y. 2019: Chidamide, a histone deacetylase inhibitor, induces growth arrest and apoptosis in multiple myeloma cells in a caspase-dependent manner Oncology Letters 18(1): 411-419
Takebe, N.; Cheng, X.; Fandy, T.E.; Srivastava, R.K.; Wu, S.; Shankar, S.; Bauer, K.; Shaughnessy, J.; Tricot, G. 2006: IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells Molecular Cancer Therapeutics 5(2): 457-466
Cho, S.-H.; Chung, K.-S.; Choi, J.-H.; Kim, D.-H.; Lee, K.-T. 2009: Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells Bmc Cancer 9: 449
García-Caballero, M.; Martínez-Poveda, B.íz.; Medina, M.A.; Quesada, A.R. 2017: The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells Frontiers in Pharmacology 8: 802
Lee, I.K.; Kang, K.A.; Lim, C.M.; Kim, K.C.; Kim, H.S.; Kim, D.H.; Kim, B.J.; Chang, W.Y.; Choi, J.H.; Hyun, J.W. 2010: Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells International Journal of Molecular Sciences 11(12): 4916-4931
Moraes, V.W.R.; Caires, A.C.F.; Paredes-Gamero, E.J.; Rodrigues, T. 2013: Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells Cell Death and Disease 4: E658
He, X-Li.; Zhang, P.; Dong, X-Zhe.; Yang, M-Hua.; Chen, S-Lin.; Bi, M-Gang. 2012: JR6, a new compound isolated from Justicia procumbens, induces apoptosis in human bladder cancer EJ cells through caspase-dependent pathway Journal of Ethnopharmacology 144(2): 284-292
Nakaya, A.; Sagawa, M.; Muto, A.; Uchida, H.; Ikeda, Y.; Kizaki, M. 2011: The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity Leukemia Research 35(2): 243-249
Arihara, Y.; Takada, K.; Kamihara, Y.; Hayasaka, N.; Nakamura, H.; Murase, K.; Ikeda, H.; Iyama, S.; Sato, T.; Miyanishi, K.; Kobune, M.; Kato, J. 2017: Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma Oncotarget 8(39): 65889-65899
Ayuk, F.A.; Fang, L.; Fehse, B.; Zander, A.R.; Kröger, N. 2005: Antithymocyte globulin induces complement-dependent cell lysis and caspase-dependent apoptosis in myeloma cells Experimental Hematology 33(12): 1531-1536
Palmer, E.M.; Baum, L.G.; van Seventer, G.A. 2003: Small intestinal submucosa induces loss of mitochondrial integrity and caspase-dependent apoptosis in human T cells Tissue Engineering 9(2): 307-314
Zhao, T.; Feng, Y.; Jin, W.; Pan, H.; Li, H.; Zhao, Y. 2016: A novel small molecule, Rosline, inhibits growth and induces caspase-dependent apoptosis in human lung cancer cells A549 through a reactive oxygen species-dependent mechanism Cell Biology International 40(6): 686-695
Onen-Bayram, F.E.; Durmaz, I.; Scherman, D.; Herscovici, J.; Cetin-Atalay, R. 2012: A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells Bioorganic and Medicinal Chemistry 20(17): 5094-5102
Komina, O.; Nosske, E.; Maurer, M.; Wesierska-Gadek, J. 2011: Roscovitine, a small molecule CDK inhibitor induces apoptosis in multidrug-resistant human multiple myeloma cells Journal of Experimental Therapeutics and Oncology 9(1): 27-35
Podar, K.; Raab, M.S.; Tonon, G.; Sattler, M.; Barilà, D.; Zhang, J.; Tai, Y.-T.; Yasui, H.; Raje, N.; DePinho, R.A.; Hideshima, T.; Chauhan, D.; Anderson, K.C. 2007: Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma Cancer Research 67(4): 1680-1688
Cho, B.O.; Jin, C.H.; Park, Y.D.; Ryu, H.W.; Byun, M.W.; Seo, K.I.; Jeong, I.Y. 2011: Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells Bioscience Biotechnology and Biochemistry 75(7): 1306-1311
Jang, J.H.; Sung, E.-G.; Song, I.-H.; Lee, T.-J.; Kim, J.-Y. 2020: Metformin induces caspase-dependent and caspase-independent apoptosis in human bladder cancer T24 cells Anti-Cancer Drugs 31(7): 655-662
Zhao, F.; Chen, Y.; Li, R.; Liu, Y.; Wen, L.; Zhang, C. 2010: Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro Toxicology 267(1-3): 70-79
Wu, S.-H.; Hang, L.-W.; Yang, J.-S.; Chen, H.-Y.; Lin, H.-Y.; Chiang, J.-H.; Lu, C.-C.; Yang, J.-L.; Lai, T.-Y.; Ko, Y.-C.; Chung, J.-G. 2010: Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways Anticancer Research 30(6): 2125-2133