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Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles

Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles

Proceedings of the National Academy of Sciences of the United States of America 110(29): 11708-11713

The synthesis of polypeptides on solid phase via mediation by isonitriles is described. The acyl donor is a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mixed anhydride intermediate. Applications of this chemistry to reiterative solid-phase peptide synthesis as well as solid-phase fragment coupling are described.

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Accession: 055838339

Download citation: RISBibTeXText

PMID: 23821753

DOI: 10.1073/pnas.1310431110

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