+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sonic hedgehog signalling pathway: a complex network

Sonic hedgehog signalling pathway: a complex network

Annals of Neurosciences 21(1): 28-31

Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of cellular differentiation to direct complex organ formation, it also has an important role in post-embryonic tissue regeneration and repair processes. Especially, Shh signalling is implicated in the induction of multifarious neuronal populations in central nervous system. There is compelling evidence of the involvement of Shh protein in the signalling network that regulates various morphogenetic processes such as the exquisite neural tube pattern formation. In the morphogenetic field, the activation of Shh signalling processes is intricately linked to the alterations at the molecular level in the structure of Shh protein that leads to its altered biophysical and biochemical reactivity. This brief article gives an overview of such complex cascade of events in Shh signalling and its transduction pathways.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055852558

Download citation: RISBibTeXText

PMID: 25206052

DOI: 10.5214/ans.0972.7531.210109

Related references

The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental Dermatology 23(12): 896-901, 2015

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA. Cellular Signalling 25(11): 2222-2230, 2014

The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer. Medecine Sciences 19(10): 920-925, 2003

Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway. Journal of Cellular and Molecular Medicine 22(1): 230-240, 2017

From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development. Respiratory Research 1(1): 30-35, 2001

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412(6843): 194-198, 2001

Activation of the transcription factor Gli1 and the sonic hedgehog signalling pathway in skin tumours. Nature (London) 389(6653): 876-881, 1997

Molecular genetic analysis of the Sonic Hedgehog/patched signalling pathway in human medulloblastomas. Proceedings of the American Association for Cancer Research Annual Meeting 42: 691, 2001

The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism. Clinical Endocrinology 82(5): 728-738, 2016

The control of neuroepithelial cell adhesion by Sonic Hedgehog does not involve the PKA-dependent signalling pathway. Biology of the Cell 92(2): 166, 2000

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene 27(10): 1489-1500, 2007

Blockade of the sonic hedgehog signalling pathway inhibits choroidal neovascularization in a laser-induced rat model. Journal of Huazhong University of Science and Technology. Medical Sciences 30(5): 659-665, 2013

Bisphenol A stimulates adrenal cortical cell proliferation via ERβ-mediated activation of the sonic hedgehog signalling pathway. Journal of Steroid Biochemistry and Molecular Biology 178: 254-262, 2018

Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells. Rheumatology 54(6): 1093-1102, 2015

Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. Journal of Pathology 199(4): 488-495, 2003