+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Computation-assisted nanopore detection of thorium ions

Computation-assisted nanopore detection of thorium ions

Analytical Chemistry: -

Thorium is a well-known radioactive and chemically toxic contaminant in the environment. The continuous exposure to thorium may cause an increased risk of developing lung and liver diseases as well as lung, pancreas and bone cancer. Due to its use in nuclear industry and other industrial applications, thorium may be accidentally released to the environment from its mining and processing plants. In this work, we developed a rapid, real-time, and label-free nanopore sensor for Th4+ detection by using an aspartic acid-containing peptide as a chelating agent and tuning the electrolyte solution pH to control the net charges of the peptide ligand and its metal ion complex. The method is highly sensitive with a detection limit of 0.45 nanomolar. Furthermore, the sensor is selective: other metal ions (e.g., UO22+, Pb2+, Cu2+, Ni2+, Hg2+, Zn2+, As3+, Mg2+, and Ca2+) with concentrations of up to three orders of magnitude greater than that of Th4+ would not interfere with Th4+ detection. In addition, simulated water samples were successfully analyzed. Our developed computation-assisted sensing strategy should find useful applications in the development of nanopore sensors for other metal ions.

(PDF emailed within 0-6 h: $19.90)

Accession: 055866238

Download citation: RISBibTeXText

PMID: 29648804

DOI: 10.1021/acs.analchem.8b00848

Related references

Nanopore detection of copper ions using a polyhistidine probe. Biosensors & Bioelectronics 53: 453-458, 2014

Peptide-Mediated Nanopore Detection of Uranyl Ions in Aqueous Media. Acs Sensors 2(5): 703-709, 2017

A tunable nanopore sensor for the detection of metal ions using translocation velocity and biphasic pulses. Nanoscale 8(45): 19139-19147, 2016

Nanopore-Based Electrochemiluminescence for Detection of MicroRNAs via Duplex-Specific Nuclease-Assisted Target Recycling. Acs Applied Materials & Interfaces 9(38): 33360-33367, 2017

MoS2-Nanosheet-Assisted Coordination of Metal Ions with Porphyrin for Rapid Detection and Removal of Cadmium Ions in Aqueous Media. Acs Applied Materials & Interfaces 9(25): 21362-21370, 2017

Single glass nanopore-based regenerable sensing platforms with a non-immobilized polyglutamic acid probe for selective detection of cupric ions. Analytica Chimica Acta 889: 98-105, 2016

Thorium concentration and the activity ratios thorium 230 thorium 232 and thorium 228 thorium 232 in sea water in the western north pacific. Journal of the Oceanographical Society of Japan 26(3): 130-136, 1970

Sensitive detection of adenosine triphosphate by exonuclease III-assisted cyclic amplification coupled with surface plasmon resonance enhanced fluorescence based on nanopore. Sensors and Actuators B: Chemical 228: 509-514, 2016

Behavior of radio nuclides of the thorium series thorium 232 thorium 228 radium 224 lead 212 bismuth 212 in rats during intra tracheal introduction of thorium di oxide. Gigiena i Sanitariya 37(2): 65-69, 1972

The Catalytic Effect Of Thorium-Ions And Zirconium-Ions On The Hydrolysis Of Nucleotides. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 340: 81-85, 1965

Separation and quantitative determination of dioxouoranium(VI) and thorium(IV) ions in the presence of different metallic ions by TLC using iso-propyldithiophosphoric acid as complexing agent. Journal of Radioanalytical and Nuclear Chemistry 238(1-2): 129-133, 1998

Multivariate outlier detection based on robust computation of Mahalanobis distances Application to positioning assisted by RTK GNSS Networks. International Journal of Applied Earth Observation and Geoinformation 16(none): 0-100, 2012

Selective recognition of uranyl ions from bulk of thorium(iv) and lanthanide(iii) ions by tetraalkyl urea: a combined experimental and quantum chemical study. Dalton Transactions 45(25): 10319-10325, 2016

A simple strategy for quantum dot assisted selective detection of cadmium ions. Chemical Communications: 3037-3039, 2008

Nanopore sculpting with noble gas ions. Journal of Applied Physics 100(2): 24914-249146, 2006