+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Spontaneous electrical activity in the human fetal cortex in vitro

Spontaneous electrical activity in the human fetal cortex in vitro

Journal of Neuroscience 31(7): 2391-2398

Our knowledge about the developing human cerebral cortex is based on the analysis of fixed postmortem material. Here we use electrical recordings from unfixed human postmortem tissue to characterize the synaptic physiology and spontaneous network activity of pioneer cortical neurons ("subplate neurons"). Our electrophysiological experiments show that functional glutamate or GABA ionotropic receptors are expressed on human subplate (SP) neurons as early as 20 gestational weeks. Extracellular (synaptic) stimulations evoked postsynaptic potentials in a very small fraction of SP neurons, suggesting that functional synaptic contacts are rare at midgestation. Although synaptic inputs were scarce, we regularly observed spontaneous (unprovoked) electrical activity among human SP neurons, comprised of sustained plateau depolarizations and bursts of action potential firing, which resembled cortical UP and DOWN states in the adult neocortex. Plateau depolarizations and bursts of action potential firing are thought to depend on the mature morphology and physiology of adult cortical network. However, our current data reveal that similar cortical rhythm is generated by a very immature ensemble of human fetal neurons. In the relative absence of sensory inputs, as in development in utero, or in slow-wave sleep (i.e., throughout the entire lifespan), the spontaneous slow oscillatory pattern (UP and DOWN states) is a fundamental aspect of human cortical physiology.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055889014

Download citation: RISBibTeXText

PMID: 21325506

DOI: 10.1523/jneurosci.3886-10.2011

Related references

Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex. Proceedings of the National Academy of Sciences of the United States of America 111(37): E3919-E3928, 2014

Spontaneous bio electrical activity of cerebral cortex in fetal and neo natal guinea pig. Physiologia Bohemoslovaca 21(4): 433, 1972

Spontaneous electrical activity in human epididymis in vitro. Journal of Andrology 6(2 Suppl.): 90-P, 1985

Spontaneous electrical activity of the human thyroid. I. Behavior of spontaneous electrical activity of the human thyroid in different functional states. Archivio "e. Maragliano" di Patologia e Clinica 14(2): 383-399, 1958

Characteristics of spontaneous and evoked activity recorded from epileptic human temporal cortex in vitro electrophysiological and morphological studies. Society for Neuroscience Abstracts 26(1-2): Abstract No -81 5, 2000

Origin of the spontaneous electrical activity of the cerebral cortex. Recent Advances Biol Psy Chiat: 42, 1960

Primary response and spontaneous electrical activity of the cerebral cortex. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 43(7): 642-650, 1957

Spontaneous electrical activity of rat brain cortex during microwave irradiation. Radiobiologiya 27(1): 87-91, 1987

Spontaneous electrical activity of the rat cerebral cortex during microwave irradiation. Radiobiologiia 27(1): 87-91, 1987

Differences in spontaneous electrical activity between diverse areas of the cerebellar cortex. Bollettino Della Societa Italiana di Biologia Sperimentale 32(9): 953-955, 1956

A Pharmacologic Analysis of the Functions of the Spontaneous Electrical Activity of the Cerebral Cortex. Journal of Nervous & Mental Disease 120(3): 157-175, 1954

Effect of thalamic lesions on spontaneous electrical activity in MES auditory cortex. American Journal of Physiology 201: 845-854, 1961

Spontaneous electrical activity and structural plasticity in the mature cerebellar cortex. Annals of the new York Academy of Sciences 1048: 131-140, 2005

Statistical properties of spontaneous electrical activity in the MES auditory cortex of the anesthetized dog. American Journal of Physiology 196(6): 1175-1180, 1959

Investigation of spontaneous and evoked electrical activity of the cerebellar cortex due to hypothermia. Arch Sci Hol 49(2): 169-184, 1965