+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sporotrichosis in HIV-infected patients: report of 21 cases of endemic sporotrichosis in Rio de Janeiro, Brazil

Sporotrichosis in HIV-infected patients: report of 21 cases of endemic sporotrichosis in Rio de Janeiro, Brazil

Medical Mycology 50(2): 170-178

Sporotrichosis is endemic in Rio de Janeiro, Brazil, and cases have been reported to be associated with HIV. This article describes the clinical manifestations and evolution of sporotrichosis in HIV-positive patients and constitutes the largest case series reported to date. There were 21 HIV-positive patients with sporotrichosis diagnosed by the recovery of the etiologic agent from 1999-2009. Sixteen patients (76.2%) were men and five (23.8%) were women, with a mean age of 41.2 years. Seven of these individuals were previously unaware of their HIV infection. Mean CD4 count was 346.4 cells/μl. The most frequent clinical presentations of sporotrichosis in these patients were the lymphocutaneous and disseminated form (seven patients each, 33.3%), followed by the widespread cutaneous form in five (23.8%), and fixed form in the remaining two (9.5%). In patients with the disseminated forms, clinical manifestations involved the skin in six, mucosa (nasal, oral, or conjunctival) in four, bone in two, and meninges in two. Eleven (52.4%) patients received itraconazole and eight (38.1%) amphotericin B contributing to an overall cure rate of 81%. Spontaneous cure was observed in one patient. The clinical forms of sporotrichosis varied according to the patients' immune status. The results demonstrate the importance of sporotrichosis as an opportunistic infection associated with AIDS in countries where the mycosis occurs.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055893049

Download citation: RISBibTeXText

PMID: 21859385

DOI: 10.3109/13693786.2011.596288

Related references

Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil. Plos Neglected Tropical Diseases 8(8): E3110, 2014

Sporotrichosis with widespread cutaneous lesions: report of 24 cases related to transmission by domestic cats in Rio de Janeiro, Brazil. International Journal of Dermatology 42(9): 677-681, 2003

Zoonotic sporotrichosis. Transmission to humans by infected domestic cat scratching: report of four cases in São Paulo, Brazil. International Journal of Dermatology 40(5): 318-322, 2001

Sporotrichosis masquerading as pyoderma gangrenosum: case report and review of 19 cases of sporotrichosis. Journal of the European Academy of Dermatology and Venereology 15(6): 581-584, 2001

Sporothrix and sporotrichosis: contributions from the first international meeting sponsored by the Working Group on Sporothrix and sporotrichosis of the International Society for Human and Animal Mycology, Rio de Janeiro, Brazil, October, 2013. Medical Mycology 53(1): 1-2, 2015

Primary conjunctival sporotrichosis: two cases from a zoonotic epidemic in Rio de Janeiro, Brazil. Cornea 24(4): 491-493, 2005

An epidemic of sporotrichosis in Rio de Janeiro, Brazil epidemiological aspects of a series of cases. Epidemiology And Infection6: 9, 1192-1196, 2008

Cat-transmitted sporotrichosis epidemic in Rio de Janeiro, Brazil: description of a series of cases. Clinical Infectious Diseases 38(4): 529-535, 2004

Sporotrichosis caused by Sporothrix globosa in Rio De Janeiro, brazil: case report. Mycopathologia 169(5): 359-363, 2010

Sporotrichosis a case report and statistical analysis of 36 patients with sporotrichosis. Nishinihon Journal of Dermatology 50(5): 915-920, 1988

Canine sporotrichosis in Rio de Janeiro, Brazil: clinical presentation, laboratory diagnosis and therapeutic response in 44 cases (1998-2003). Medical Mycology 44(1): 87-92, 2006

Sporotrichosis in pregnancy: case reports of 5 patients in a zoonotic epidemic in Rio de Janeiro, Brazil. Anais Brasileiros de Dermatologia 86(5): 995-998, 2012

The epidemiological scenario of feline sporotrichosis in Rio de Janeiro, State of Rio de Janeiro, Brazil. Revista Da Sociedade Brasileira de Medicina Tropical 47(3): 392-393, 2014

Immunology of Sporotrichosis. Iv. the Sporotrichin Test in Germany and Brazil in Persons Without Sporotrichosis. Revista do Instituto de Medicina Tropical de Sao Paulo 5: 217-219, 1963

The immunology of sporotrichosis. IV. The sporotrichin test in Germany and Brazil on persons without sporotrichosis. Rev. Inst. Med. trop., S. Paulo. 5: 5, 217-219, 1963