+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Statin drug interactions and related adverse reactions

Statin drug interactions and related adverse reactions

Expert Opinion on Drug Safety 11(6): 933-946

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, their possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions and related adverse reactions. Avoiding drug-drug interactions and consequent adverse drug reactions is essential in order to optimize compliance, and thus improve the treatment of patients at high cardiovascular risk. The different pharmacokinetic profiles among statins should be carefully considered, in order to understand the possible spectrum of drug interactions. The growing trend toward earlier statin treatment for the prevention of cardiovascular disease means that physicians must anticipate future polypharmacy when their patients require additional medications for comorbid conditions.

(PDF emailed within 0-6 h: $19.90)

Accession: 055911069

Download citation: RISBibTeXText

PMID: 22866966

DOI: 10.1517/14740338.2012.712959

Related references

Statin drug interactions and related adverse reactions: an update. Expert Opinion on Drug Safety 17(1): 25-37, 2017

Phenotyping Adverse Drug Reactions: Statin-Related Myotoxicity. AMIA Joint Summits on Translational Science Proceedings. AMIA Joint Summits on Translational Science 2015: 466-470, 2015

Introduction of "the manual for handling disorders due to adverse drug reactions"--focus on the antibiotics related severe adverse drug reactions. Japanese Journal of Antibiotics 61(4): 269-288, 2008

Adverse Drug reactions in an Ageing PopulaTion (ADAPT) study protocol: a cross-sectional and prospective cohort study of hospital admissions related to adverse drug reactions in older patients. Bmj Open 7(6): E017322, 2018

Statin-associated psychiatric adverse events: A case/non case evaluation of an Italian database of spontaneous reporting of adverse drug reactions. 2007

Use of pharmacogenetic testing to prevent adverse drug reactions during statin therapy. Terapevticheskii Arkhiv 89(1): 82-87, 2017

Hospital-based survey of doctors' attitudes to adverse drug reactions and perception of drug-related risk for adverse reaction occurrence. Pharmacoepidemiology and Drug Safety 8 Suppl 1: S27-S35, 2004

Drug Adverse Reaction Target Database (DART) : proteins related to adverse drug reactions. Drug Safety 26(10): 685-690, 2003

Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Annals of Emergency Medicine 38(6): 666-671, 2001

Statin hepatotoxicity and the dilemma of causality in rare hepatic adverse drug reactions. Journal of Hepatology 57(3): 702-3; Author Reply 703-4, 2013

Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients. Age and Ageing 40(2): 274-277, 2011

Rhabdomyolysis after co-administration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions. British Journal of Clinical Pharmacology 84(5): 1057-1063, 2018

Adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort study. European Journal of Clinical Pharmacology 68(12): 1667-1676, 2013

A 6-year retrospective study of adverse drug reactions due to drug-drug interactions between nervous system drugs. International Journal of Clinical Pharmacology and Therapeutics 52(5): 392-401, 2014

Analysis of adverse drug reactions using drug and drug target interactions and graph-based methods. Artificial Intelligence in Medicine 48(2-3): 161-166, 2010