+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Statin use after diagnosis of breast cancer and survival: a population-based cohort study



Statin use after diagnosis of breast cancer and survival: a population-based cohort study



Epidemiology 26(1): 68-78



Preclinical studies have shown that statins, particularly simvastatin, can prevent growth in breast cancer cell lines and animal models. We investigated whether statins used after breast cancer diagnosis reduced the risk of breast cancer-specific, or all-cause, mortality in a large cohort of breast cancer patients. A cohort of 17,880 breast cancer patients, newly diagnosed between 1998 and 2009, was identified from English cancer registries (from the National Cancer Data Repository). This cohort was linked to the UK Clinical Practice Research Datalink, providing prescription records, and to the Office of National Statistics mortality data (up to 2013), identifying 3694 deaths, including 1469 deaths attributable to breast cancer. Unadjusted and adjusted hazard ratios (HRs) for breast cancer-specific, and all-cause, mortality in statin users after breast cancer diagnosis were calculated using time-dependent Cox regression models. Sensitivity analyses were conducted using multiple imputation methods, propensity score methods and a case-control approach. There was some evidence that statin use after a diagnosis of breast cancer had reduced mortality due to breast cancer and all causes (fully adjusted HR = 0.84 [95% confidence interval = 0.68-1.04] and 0.84 [0.72-0.97], respectively). These associations were more marked for simvastatin 0.79 (0.63-1.00) and 0.81 (0.70-0.95), respectively. In this large population-based breast cancer cohort, there was some evidence of reduced mortality in statin users after breast cancer diagnosis. However, these associations were weak in magnitude and were attenuated in some sensitivity analyses.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055911368

Download citation: RISBibTeXText

PMID: 25304447

DOI: 10.1097/EDE.0000000000000189


Related references

Statin use after colorectal cancer diagnosis and survival: a population-based cohort study. Journal of Clinical Oncology 32(28): 3177-3183, 2014

Statin use after esophageal cancer diagnosis and survival: A population based cohort study. Cancer Epidemiology 48: 124-130, 2017

Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study. Gastroenterology 150(4): 854-65.E1; Quiz E16-7, 2016

Digoxin use after diagnosis of breast cancer and survival: a population-based cohort study. Breast Cancer Research and Treatment 151(3): 661-669, 2016

Statin use and survival from lung cancer: a population-based cohort study. Cancer Epidemiology, Biomarkers and Prevention 24(5): 833-841, 2016

Adult children's socioeconomic resources and mothers' survival after a breast cancer diagnosis: a Swedish population-based cohort study. Bmj Open 7(3): E014968, 2017

Statin use, Candidate Mevalonate Pathway Biomarkers, and Colon Cancer Survival in a Population-Based Cohort Study. Gastroenterology 152(5): S1023-S1024, 2017

Statin use and survival in colorectal cancer: Results from a population-based cohort study and an updated systematic review and meta-analysis. Cancer Epidemiology 45: 71-81, 2016

Survival in patients with breast cancer with bone metastasis: a Danish population-based cohort study on the prognostic impact of initial stage of disease at breast cancer diagnosis and length of the bone metastasis-free interval. Bmj Open 5(4): E007702, 2016

Statin use after diagnosis is associated with an increased survival in esophageal cancer patients: a Belgian population-based study. Cancer Causes and Control 2019, 2019

Time from breast cancer diagnosis to therapeutic surgery and breast cancer prognosis: A population-based cohort study. International Journal of Cancer 143(5): 1093-1104, 2018

Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study. Breast Cancer Research and Treatment 105(1): 69-80, 2006

Family history of breast cancer and young age at diagnosis of breast cancer increase risk of second primary malignancies in women: a population-based cohort study. British Journal of Cancer 95(9): 1291-1295, 2006

Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivors. Breast Cancer Research and Treatment 109(3): 573-579, 2007

Survival of male breast cancer patients: population-based cohort study. Cancer Science 100(2): 292-295, 2011