+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Statin use in patients with cirrhosis: a retrospective cohort study

Statin use in patients with cirrhosis: a retrospective cohort study

Digestive Diseases and Sciences 59(8): 1958-1965

Statins reduce cardiovascular risk. Patients with cirrhosis have decreased hepatic clearance of statins and potentially increased risk for complications. No studies assess mortality in patients with biopsy-confirmed cirrhosis. Compare mortality in patients with cirrhosis on statins to those not on statins. A retrospective cohort study evaluated patients from 1988 to 2011 at Partners Healthcare Hospitals. The Partners Research Patient Data Registry identified patients with biopsy-proven cirrhosis on statins at biopsy and at least 3 months following. Controls were matched 1:2 by age, gender and Child-Pugh class. Decompensation was defined as ascites, jaundice/bilirubin >2.5 mg/dL, and/or hepatic encephalopathy or variceal hemorrhage. Primary outcome was mortality. Secondary outcome was decompensation in baseline-compensated patients. Chi-square and two-way ANOVA testing compared groups. Cox proportional hazards models for mortality controlled for age, Child-Pugh class, diabetes, coronary artery disease, non-alcoholic steatohepatitis and hepatocellular carcinoma. Kaplan-Meier curves graphed mortality. Eighty-one statin users and 162 controls were included. Median follow-up: 36 months in statin users and 30 months in controls. 70.4% of patients were Child-Pugh A. Model for End-Stage Liver Disease (MELD), albumin, varices and beta-blocker use were not significantly different between groups. Statin users had lower mortality on multivariate analysis (HR 0.53, p = 0.01), and Child-Pugh A patients had longer survival on Kaplan-Meier analysis. Cox multivariate analysis for decompensation showed lower risk of decompensation with statins while increased decompensation with low albumin, high MELD score and beta-blocker use. In patients with cirrhosis, statin therapy is not associated with increased mortality and may delay decompensation.

(PDF emailed within 0-6 h: $19.90)

Accession: 055911489

Download citation: RISBibTeXText

PMID: 24838495

DOI: 10.1007/s10620-014-3179-2

Related references

Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study. International Journal of Environmental Research and Public Health 16(9), 2019

Prior statin use and the outcomes in patients with first-attack acute pancreatitis: A retrospective cohort study. European Journal of Internal Medicine 26(6): 425-428, 2016

The influence of physicians' guideline compliance on patients' statin adherence: a retrospective cohort study. American Journal of Geriatric PharmacoTherapy 3(4): 229-239, 2006

Are high-risk hypertensive patients being prescribed concomitant statin therapy?: a retrospective cohort study. American Journal of Cardiovascular Drugs 9(5): 299-308, 2010

Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients. Drug Safety 36(10): 1017-1024, 2014

Quantifying Unmet Need in Statin-Treated Hyperlipidemia Patients and the Potential Benefit of Further LDL-C Reduction Through an EHR-Based Retrospective Cohort Study. Journal of Managed Care and Specialty Pharmacy 25(5): 544-554, 2019

Does use of pooled cohort risk score overestimate the use of statin?: a retrospective cohort study in a primary care setting. Bmc Family Practice 15: 172, 2015

Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study. Journal of Thoracic and Cardiovascular Surgery 131(3): 679-685, 2006

Plasma Transfusion in Patients With Cirrhosis in China: A Retrospective Multicenter Cohort Study. Transfusion Medicine Reviews 31(2): 107-112, 2017

Is anti-HCV therapy useful for preventing liver-related death in patients with HCV cirrhosis? Result of a retrospective cohort study in 445 patients. Hepatology 34(4 Pt 2): 420A, 2001

Renal impairment is associated with increased risk of mortality in patients with cirrhosis: A retrospective cohort study. Medicine 98(6): E14475, 2019

Surgical strategy for gastric cancer patients with liver cirrhosis: a retrospective cohort study. International Journal of Surgery 12(8): 810-814, 2015

Splenomegaly as risk factor of liver cirrhosis. A retrospective cohort study of 2,525 patients who underwent laparoscopy. In Vivo 25(6): 1009-1012, 2012

Safety of laparoscopic resection for colorectal cancer in patients with liver cirrhosis: A retrospective cohort study. International Journal of Surgery 55: 110-116, 2018

The Hispanic Paradox in Patients with Liver Cirrhosis: Current Evidence from a Large Regional Retrospective Cohort Study. Transplantation 2019, 2019