+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Statins and vascular dementia: a review



Statins and vascular dementia: a review



Journal of Alzheimer's Disease 42 Suppl 3: S315-S320



The impact of statin therapy on dementia has been a hot topic of debate over the last decade and still remains highly controversial. Among all causes of dementia, vascular dementia (VaD) is the one type that is more likely to benefit from statins. To date no randomized clinical trials have been published and no systematic review has investigated a possible preventive effect of statins on the VaD subtype. In the present literature review, we tried to identify all available data on the effect of statins specifically in patients with VaD, and to further discuss this possible association. Our literature search highlighted two cross-sectional studies, two prospective cohort studies, and one retrospective cohort study. Two of the studies found a significant positive effect of statin treatment on VaD, depicted by the lower incidence of VaD in statin users, while the others reported non-significant associations. The relatively small numbers of VaD patients and statin users, as well as the presence of confounders and biases, make the interpretation of results extremely difficult. Statins may exert a benefit in the prevention of all-type dementia and VaD, through several mechanisms except for hyperlipidemia reduction. A well-designed randomized clinical trial is the ideal study design to address the effect of statin therapy in VaD and to draw final conclusions.

(PDF emailed within 0-6 h: $19.90)

Accession: 055911909

Download citation: RISBibTeXText

PMID: 24662103

DOI: 10.3233/JAD-132366


Related references

Systematic review of statins for the prevention of vascular dementia or dementia. Geriatrics & Gerontology International 10(2): 199-208, 2010

ACP Journal Club. Review: In older persons at vascular risk, statins do not prevent dementia or cognitive decline at 3.5 to 5 years. Annals of Internal Medicine 164(8): Jc42-Jc42, 2016

Review: statins do not protect against development of dementia. Evidence-Based Mental Health 12(4): 114-114, 2009

Cochrane review on 'Statins for the treatment of dementia'. International Journal of Geriatric Psychiatry 28(2): 119-126, 2013

The effects of statins on prevention of stroke and dementia: a review. Journal of Cardiopulmonary Rehabilitation and Prevention 32(5): 240-249, 2013

ACP Journal Club. Review: statins are not associated with cognitive impairment, Alzheimer disease, or dementia. Annals of Internal Medicine 160(10): Jc10-Jc11, 2014

ACP Journal Club. Review: statins are not associated with cognitive impairment or dementia in cognitively intact adults. Annals of Internal Medicine 160(10): Jc11, Jc10-Jc11, Jc10, 2014

Vascular dementia in progress: A review on vascular dementia. Fortschritte der Neurologie Psychiatrie 62(6): 197-219, 1994

A review of the epidemiological transition in dementia: Cross-national comparisons of the indices related to Alzheimer's disease and vascular dementia. Acta Psychiatrica Scandinavica 104(1): 4-11, July, 2001

Frailty as a Predictor of Alzheimer Disease, Vascular Dementia, and All Dementia Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association 17(10): 881-888, 2016

Statins and dementia: does length of statins use matter?. Atherosclerosis 230(2): 397-398, 2014

Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. Journal of Neurochemistry 115(4): 814-828, 2010

Effects of statins on vascular structure and function: a systematic review. American Journal of Medicine 117(10): 775-790, 2004

Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementia. Journal of the Neurological Sciences 236(1-2): 43-48, 2005