+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Statins as a novel therapeutic strategy in acute lung injury



Statins as a novel therapeutic strategy in acute lung injury



Pulmonary Circulation 2(4): 397-406



Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dysfunction in ALI has been facilitated by study of the effects of statins in relevant cellular and animals models. Many of the pleotropic properties of these drugs, including direct effects on endothelial cell (EC) cytoskeletal rearrangement, NADPH oxidase, and nitric oxide activity, as well as effects on differential EC gene expression, are relevant to the pathobiology of ALI and suggest a potential therapeutic role for statins in this context. Moreover, results from preclinical studies and observations in relevant patient populations support the protective potential of statins in ALI, paving the way now for definitive clinical trials.

(PDF emailed within 0-6 h: $19.90)

Accession: 055911935

Download citation: RISBibTeXText

PMID: 23372924

DOI: 10.4103/2045-8932.105028


Related references

Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest 128(5): 3089-3091, 2005

Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. Journal of Clinical Investigation 116(9): 2316-2319, 2006

Akt2 deficiency as a therapeutic strategy protects against acute lung injury. ImmunoTherapy 6(4): 377-380, 2014

Activated protein C inhalation: a novel therapeutic strategy for acute lung injury. Medical Science Monitor 17(6): Hy11-Hy13, 2011

Statins for the prevention and treatment of acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis. Respirology 21(6): 1026-1033, 2016

Statins and acute lung injury: Holy Grail or the next to fail?. Critical Care Medicine 40(5): 1661-1663, 2012

Additional experimental evidence that statins protect against acute lung injury. Respiratory Care 57(2): 331; Author Reply 331-2, 2012

A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo. Annals of Surgery 235(2): 285-291, 2002

Fluid management strategy in acute lung injury and acute respiratory distress syndrome. Zhonghua Er Ke Za Zhi 49(2): 125-127, 2011

Pro-resolution of inflammation: a potential strategy for treatment of acute lung injury/acute respiratory distress syndrome. Chinese Medical Journal 127(5): 801-802, 2015

Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Critical Care Medicine 33(1): 63-70; Discussion 239-40, 2005

Application of the acute respiratory distress syndrome network low-tidal volume strategy to pediatric acute lung injury. Respiratory Care Clinics of North America 12(3): 349-357, 2006

A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitor. Virology Journal 7(): 30-30, 2010

Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?. American Journal of Respiratory Cell and Molecular Biology 48(3): 271-279, 2013

Effect of statins on the mortality and mechanical ventilation duration of acute lung injury patients: a meta-analysis of five randomized controlled trials. International Journal of Clinical Pharmacology and Therapeutics 53(11): 923-932, 2015