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Strains of Klebsiella pneumoniae producing extended spectrum beta-lactamases, isolated from organ recipients



Strains of Klebsiella pneumoniae producing extended spectrum beta-lactamases, isolated from organ recipients



Transplantation Proceedings 43(8): 3128-3129



The aims of this work were to define the effectiveness of identification of the extended-spectrum beta-lactamases (ESBL) phenotype, and to define the genotype of Klebsiella pneumoniae β-lactamase. We identified ESBL phenotypes in 110 strains of K pneumoniae isolated from samples from patients of transplantation wards, using the double-disk synergy test (DDST). For the chosen strains, polymerase chain reaction (PCR) was applied to detect genes determining SHV, CTX-M, and TEM. We showed synergism of clavulanic acid and investigated antibiotics including ceftazidime (89.1%), cefotaxime (80%), and aztreonam (82.7%) against ESBL-positive strains PCR revealed that TEM and CTX-M were present in 88.89% of strains. The ESBL mechanism of resistance is frequent among K pneumoniae strains isolated from transplant recipients. Strains with simultaneous synthesis of more than one beta-lactamase predominated.

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Accession: 055932084

Download citation: RISBibTeXText

PMID: 21996244

DOI: 10.1016/j.transproceed.2011.08.003


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