Structural elucidation of the capsular polysaccharide from Streptococcus pneumoniae serotype 47A by NMR spectroscopy

Petersen, B.O.; Hindsgaul, O.; Paulsen, B.S.; Redondo, A.R.; Skovsted, I.C.

Carbohydrate Research 386: 62-67

2014


ISSN/ISBN: 1873-426X
PMID: 24486982
DOI: 10.1016/j.carres.2013.11.013
Accession: 055951503

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Abstract
The structure of the serotype 47A (Danish nomenclature system) capsular polysaccharide from Streptococcus pneumoniae was elucidated by NMR spectroscopy. The following structure of the repeating heptasaccharide was deduced: [structure: see text]. The serotype 47A capsular polysaccharide is one of 91 structurally and serologically distinct capsular polysaccharides that have been recognized in S. pneumoniae, a significant human pathogenic bacterium and model system in medical microbiology. Structure and NMR spectra are compared to previously solved capsular polysaccharide structures of other serotypes.