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Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

McDevitt, C.A.; Shintre, C.A.; Grossmann, J.G.ün.; Pollock, N.L.; Prince, S.M.; Callaghan, R.; Ford, R.C.

Febs Letters 582(19): 2950-2956

2008


ISSN/ISBN: 0014-5793
PMID: 18657537
DOI: 10.1016/j.febslet.2008.07.022
Accession: 055952323

P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.

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