+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Studies on the Relation of Tetanus Bacilli in the Digestive Tract to Tetanus Antitoxin in the Blood

Studies on the Relation of Tetanus Bacilli in the Digestive Tract to Tetanus Antitoxin in the Blood

Journal of Experimental Medicine 37(4): 479-489

1. The sera of twenty-six individuals who carried tetanus bacilli in their digestive tracts all contained appreciable amounts of antitoxin. 2. The sera of thirty individuals in whose stools no tetanus-like organisms were found were, with two exceptions, free from tetanus antitoxin. 3. Although we have been unable to measure accurately the antitoxin content of these human carriers of tetanus bacilli, 0.1 cc. of serum neutralizes 10 or more M.L.D. of toxin and it is evident that they have acquired an active immunity due to the bacilli in the intestinal tract. 4. These results definitely prove that tetanus bacilli grow in the intestinal tract of man. 5. Many of the individuals who have no tetanus bacilli in their intestinal tracts and whose serum is free from antitoxin show agglutinins to tetanus bacilli. It is probable that they have been carriers of the bacilli in the past and that the agglutinins have persisted longer than the antitoxins. It seems likely, therefore, that these individuals are potentially immune to tetanus. 6. If tetanus bacilli can be established in the digestive tract of man we have a means of immunization which might be useful in armies or in regions where tetanus infections are common, though we do not recommend this method of immunization at present.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055965252

Download citation: RISBibTeXText

PMID: 19868740

DOI: 10.1084/jem.37.4.479

Related references

Studies on tetanus. V. In vivo localization of purified tetanus toxin in mice with fluorescein-labelled tetanus antitoxin. J. Neuropath. exp. Neurol 25: 422-430, 1966

Studies on tetanus. V. In vivo localization of purified tetanus neurotoxin in mice with fluorescein-labelled tetanus antitoxin. Journal of Neuropathology and Experimental Neurology 25(3): 422-430, 1966

Relation between the level of specific antitoxin in the blood and the degree of immunity to tetanus toxin in wilte mice immunized with adsorbed tetanus toxoid. Bulletin of Experimental Biology and Medicine 43(2): 193-196, 1957

Studies on the antibody composition and neutralizing activity of tetanus antitoxin sera from various species of animals in relation to the antigenic substructure of the tetanus toxin molecule. Biken Journal 26(4): 133-143, 1983

The distribution and elimination of intralumbarly administered homologous tetanus antitoxin. Immunological and physico-chemical studies of the cerebrospinal fluid and serum of tetanus patients after lumbar administration of human tetanus hyperimmune globulin. Klinische Wochenschrift 48(21): 1312-1314, 1970

Studies on tetanus antitoxin. I. Isolation of two neutralizing antibodies from tetanus antitoxin. Journal of Immunology 104(6): 1417-1423, 1970

Studies of tetanus toxin and antitoxin in human sera. II. Comparison of hemagglutination and mouse neutralization tests for determining circulating human tetanus antitoxin. Medical Technicians Bulletin 8(4): 149-154, 1957

Studies on tetanus and diphtheria vaccination. Part 1. Studies on measurement of human tetanus antitoxin value and diphtheria antitoxin value by the passive hemagglutination method. Kansenshogaku Zasshi. Journal of the Japanese Association for Infectious Diseases 52(3): 70-78, 1978

Adequate dosage of tetanus antitoxin and tetanus-immune human gamma globulin TIG in the treatment of tetanus. Masui. Japanese Journal of Anesthesiology 23(5): 381-387, 1974

Determination of tetanus immunity in guinea pigs after inoculation with tetanus antitoxin to which CaCl2 has been added or with tetanus adsorbate vaccine. Lucrarile Stiintifice Inst Seruri Vaccinuri Pasteur Bucuresti 3: 337-345, 1958

Serum levels of tetanus antibodies in tetanus patients treated with tetanus antitoxin and toxoid. Przeglad Epidemiologiczny 28(2): 149-158, 1974

Inhibition of the reaction between tetanus toxoid-sensitized lymphocytes and tetanus toxin by tetanus antitoxin. Zeitschrift für Immunitatsforschung Experimentelle und Klinische Immunologie 145(2): 131-138, 1975

The Immunity Produced By The Growth Of Tetanus Bacilli In The Digestive Tract. Journal of Experimental Medicine 43(3): 361-377, 1926

Tetanus antitoxin titres of umbilical cord blood as an indication of immunity against tetanus neonatorum. Indian Journal of Medical Sciences 29(1): 14-15, 1975

The flocculation of tetanus toxin with antitoxin, practiced with antitetanus serum obtained from different animals. On tetanus antitoxin and its qualitative alterations during immunization. Compt Rend Soc Biol 135(15/16): 1278-1285, 1941