+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation

Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation

Journal of Colloid and Interface Science 407: 236-242

Despite their great potentials as biomacromolecues delivery vehicles, there are few, if any, reports on mesoporous silica nanoparticles (MSNs) simultaneously integrated with the merits of large pore size, small particle diameters and well-ordered mesostructure. Here, we designed a facile strategy for the synthesis of monodispersed MSNs using cationic surfactants (CSs) as templating agents, neutral amine of N,N-dimethylhexadecylamine (DMHA) as a pore size mediator and tri-block copolymer of F127 (EO106PO70EO106) as a particle growth inhibitor/dispersant. The obtained colloidal nanoparticles exhibited a highly ordered mesostructure and tunable pore diameter up to 4.6 nm (BJH) and monodispersed particle sizes less than 150 nm. A model protein of cytochrome c (CytC) was exemplified to be accommodated in the resultant MSNs and its loading amount was correlated with their pore size. The efficient cancer cellular uptake of the large-pore MSNs prefigured their potentials as intracellular delivery vehicles for membrane-impermeable proteins.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055982950

Download citation: RISBibTeXText

PMID: 23866201

DOI: 10.1016/j.jcis.2013.06.028

Related references

Monodispersed and ordered large-pore mesoporous silica nanospheres with tunable pore structure for magnetic functionalization and gene delivery. Advanced Materials 26(29): 4947-4953, 2014

Template synthesis of three-dimensional cubic ordered mesoporous carbon with tunable pore sizes. Nanoscale Research Letters 5(1): 103-107, 2009

Ordered mesoporous polymers of tunable pore size from colloidal silica templates. Science 283(5404): 3-5, 1999

Synthesis of mesoporous carbon nanoparticles with large and tunable pore sizes. Nanoscale 7(27): 11580-11590, 2015

Investigation of the stability of Platinum nanoparticles incorporated in mesoporous silica with different pore sizes. Journal of Colloid and Interface Science 421: 22-26, 2014

Synthesis and characterization of pore size-tunable magnetic mesoporous silica nanoparticles. Journal of Colloid and Interface Science 361(1): 16-24, 2011

In vitro and in vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes. International Journal of Pharmaceutics 445(1-2): 12-19, 2013

A simple organicinorganic co-assembling route to pore-expanded ordered mesoporous carbons with 2-D hexagonal mesostructure. Powder Technology 259: 74-80, 2014

Controlled intracellular release of doxorubicin in multidrug-resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles. Acs Nano 5(12): 9788-9798, 2011

Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size using amphiphilic block copolymers as core templates. Dalton Transactions 43(31): 11834-11842, 2014

Synthesis of silica nanoparticles having a well-ordered mesostructure using a double surfactant system. Journal of the American Chemical Society 126(2): 462-463, 2004

Facile preparation of ultra-large pore mesoporous silica nanoparticles and their application to the encapsulation of large guest molecules. Acs Applied Materials and Interfaces 6(3): 1740-1746, 2014

Encapsulation method for the dispersion of NiO onto ordered mesoporous silica, SBA-15, using polyethylene oxide (PEO). Journal of Colloid and Interface Science 295(2): 464-471, 2006

Encapsulation of Pd complex in ionic liquid on highly ordered mesoporous silica MCM-41. Journal of Nanoscience and Nanotechnology 7(11): 3880-3883, 2007

Triconstituent co-assembly to ordered mesostructured polymer-silica and carbon-silica nanocomposites and large-pore mesoporous carbons with high surface areas. Journal of the American Chemical Society 128(35): 11652-11662, 2006