+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Successful surgical treatment of craniopharyngioma in very young children



Successful surgical treatment of craniopharyngioma in very young children



Journal of Neurosurgery. Pediatrics 3(5): 397-406



Given the potential morbidity of cranial irradiation in young children, the risk-benefit analysis of limited surgery plus irradiation versus radical resection may favor the latter strategy. The purpose of this study was to assess the oncological, endocrinological, and functional outcomes of patients 5 years of age and younger who underwent radical resection of craniopharyngiomas. Between 1991 and 2008, 19 children age < or = 5 years were diagnosed with a craniopharyngioma and underwent radical resection by the senior author (J.H.W.). Data were retrospectively collected on these 19 patients (11 males, 8 females; mean age 3.2 years) to assess the efficacy and impact of surgical treatment. Eighteen (95%) of 19 patients underwent gross-total resection (GTR) confirmed by intraoperative inspection and postoperative imaging. There was no operative death and 18 of (95%) 19 patients were alive at a mean follow-up of 9.4 years (median 8.3 years). Six patients (31%) had a total of 7 tumor recurrences treated by repeat GTR in 5 patients and Gamma knife surgery in 1 patient. No patient required conventional, fractionated radiation therapy. Disease control was achieved surgically in 17 (89.5%) patients and with surgery and Gamma knife surgery in 1 patient, yielding an overall rate of disease control of 95% without the use of conventional radiotherapy. New-onset diabetes insipidus occurred in 50% of patients. Vision worsened in 1 patient, and there was no long-term neurological morbidity. In this retrospective series, children aged < or = 5 years with craniopharyngiomas can have excellent outcomes with minimal morbidity after radical resection by an experienced surgeon. Disease control in this population can be successfully achieved with GTR alone in the majority of cases, avoiding the detrimental effects of radiotherapy in this vulnerable population.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055999190

Download citation: RISBibTeXText

PMID: 19409019

DOI: 10.3171/2009.1.peds08401


Related references

Successful surgical treatment of an odontogenic ossified craniopharyngioma. Case report. Journal of Neurosurgery 55(5): 832-835, 1981

Craniopharyngioma in children. Surgical treatment by a transbasal anterior approach. Child's Nervous System 14(12): 709-712, 1998

Analysis and Long-Term Follow-Up of the Surgical Treatment of Children With Craniopharyngioma. Journal of Craniofacial Surgery (): -, 2016

A reformed surgical treatment modality for children with giant cystic craniopharyngioma. Child's Nervous System 33(9): 1491-1500, 2017

Gait asymmetry following successful surgical treatment of ankle fractures in young adults. Clinical Orthopaedics and Related Research 1995(311): 262-269, 1995

Successful treatment of dwarfism and hypogonadism after total removal of craniopharyngioma. Neurologia Medico-Chirurgica 25(1): 61-65, 1985

Successful treatment of a giant cystic craniopharyngioma. Case report. Journal of Neurosurgical Sciences 29(3): 263-265, 1985

Bases of surgical management of craniopharyngioma in children. Acta Neurochirurgica. Supplementum 28(2): 348, 1979

Craniopharyngioma in adults and children: a study of 122 surgical cases. Journal of Neurosurgery 97(1): 3, 2002

Insulin, obesity, GH, and IGF-1 in children after surgical removal of craniopharyngioma. Diabetologia 42(Suppl. 1): A202, 1999

Multiple coronary aneurysm resulting in myocardial infarction in a young man - successful surgical treatment using a bypass graft. Nihon Kyobu Geka Gakkai 24(2): 229-235, 1976

Endocrine Disorders Developing after Surgical Intervention of Craniopharyngioma in Children. Pediatric Endocrinology Reviews 14(3): 298-301, 2017

MR and CT diagnosis of carotid pseudoaneurysm in children following surgical resection of craniopharyngioma. Pediatric Radiology 25(4): 249-251, 1995

Intellectual and psychosocial functions of children, adolescents and young adults before and after operation for craniopharyngioma. Child: Care Health and Development 7(6): 307-316, 1981

Surgical treatment of nasopharyngeal craniopharyngioma. Journal of Laryngology & Otology 91(03): 227-234, 1977