+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: a retrospective analysis of 303 patients

Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: a retrospective analysis of 303 patients

Strahlentherapie und Onkologie 190(1): 59-63

For palliative care of spinal bone metastases, stability assessment is of crucial importance. Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported to affect patient outcome and these parameters have therefore been used for treatment stratification. We report on stability-dependent fracture and survival rates in over 300 non-small cell lung cancer (NSCLC) patients. Data from 303 patients with 868 osteolytic metastases treated with radiotherapy (RT) between 2000 and 2012 were evaluated retrospectively. In NSCLC patients with bone metastases only, the retrospective 6- and 12-month overall survival (OS) rates were 76.7 and 47.2%, respectively. In patients with additional non-bone distant metastases, these values were 60.0 and 34.0%, respectively. Survival rates were significantly lower in patients with multiple bone metastases and in those suffering pathological fractures (p=0.017). No significant impact of histological type, location of spinal lesions or treatment regime was detected. Furthermore, stability assessment revealed no influence of vertebral column stability on patient outcome (p=0.739). Our analysis demonstrated a correlation between the pathological fractures of bone lesions, the number of bone metastases, additional distant metastases and survival. The results offer a rationale for future prospective investigations.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056043249

Download citation: RISBibTeXText

PMID: 24052009

DOI: 10.1007/s00066-013-0431-1

Related references

Prognostic factors for survival of patients with extensive stage small cell lung cancer--a retrospective single institution analysis. Asian Pacific Journal of Cancer Prevention 13(10): 4959-4962, 2012

Survival and prognostic factors in patients with stable and unstable spinal bone metastases from solid tumors: a retrospective analysis of 915 cases. Bmc Cancer 16: 528, 2016

Prognostic factors associated with survival in patients with symptomatic spinal bone metastases: a retrospective cohort study of 1,043 patients. Neuro-Oncology 16(7): 991-998, 2014

Metastatic Spinal Cord Compression from Non-Small-Cell Lung Cancer Treated with Surgery and Adjuvant Therapies: A Retrospective Analysis of Outcomes and Prognostic Factors in 116 Patients. Journal of Bone and Joint Surgery. American Volume 97(17): 1418-1425, 2015

Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology). Journal of Cancer Research and Therapeutics 14(3): 578-582, 2018

Spinal bone metastases in colorectal cancer: a retrospective analysis of stability, prognostic factors and survival after palliative radiotherapy. Radiation Oncology 12(1): 115, 2017

Prognostic factors for survival in a Chinese population presenting with advanced non-small cell lung cancer with an emphasis on smoking status: A regional, single-institution, retrospective analysis of 4552 patients. Thoracic Cancer 3(2): 162-168, 2012

Prognostic factors in patients with inoperable non-small cell lung cancer--an analysis of long-term survival patients. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 33(11): 1595-1602, 2006

Prognostic Factors and Skeletal-Related Events in Patients with Small Cell Lung Cancer with Bone Metastases at the Time of Diagnosis. Oncology 90(2): 103-111, 2016

Number of extraspinal organs with metastases: a prognostic factor of survival in patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC). Anticancer Research 34(5): 2503-2507, 2014

Prognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China. Chinese Journal of Cancer Research 23(4): 265-270, 2011

Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patients. Clinical Cancer Research 18(22): 6348-6355, 2012

The prognostic factors in the elderly patients with small cell lung cancer: a retrospective analysis from a single cancer institute. International Journal of Clinical and Experimental Pathology 8(9): 11033-11041, 2015

Analysis of prognostic factors for long term survival in patients with small cell lung cancer. Pneumonologia i Alergologia Polska 62(5-6): 233-238, 1994

Pretreatment prognostic factors for survival in non-small-cell lung cancer: A multivariate analysis of 229 patients. Onkologie 21(3): 204-210, 1998