Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

Maillard, L.T.; Bertout, S.éb.; Quinonéro, O.él.; Akalin, G.ül.şe.; Turan-Zitouni, G.ül.; Fulcrand, P.; Demirci, F.; Martinez, J.; Masurier, N.

Bioorganic and Medicinal Chemistry Letters 23(6): 1803-1807

2013


ISSN/ISBN: 1464-3405
PMID: 23403080
DOI: 10.1016/j.bmcl.2013.01.039
Accession: 056063581

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Abstract
Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.